{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:08:36Z","timestamp":1778936916062,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010733","name":"B\u00f8rnecancerfonden","doi-asserted-by":"publisher","award":["2022\u20108066"],"award-info":[{"award-number":["2022\u20108066"]}],"id":[{"id":"10.13039\/100010733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Chemotherapy\u2010induced neutropenia, monitored by peripheral blood absolute neutrophil count (ANC), increases the risk of bloodstream infections (BSIs). However, ANC may not reflect the total neutrophil population, as it omits neutrophils at extravascular sites. We therefore evaluated plasma calprotectin, a neutrophil\u2010derived protein, as a complementary marker of neutropenia severity and BSI risk. In 114 children with acute lymphoblastic leukaemia (ALL) treated according to the NOPHO ALL2008 protocol, plasma calprotectin was measured weekly during the 4\u2010week anthracycline\u2010based induction therapy. Daily ANC and BSI events were obtained from medical records. All patients developed profound neutropenia (ANC &lt;0.5\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L). At the time of BSI occurrence (median day 12), ANC did not differ between patients with BSI (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200929, 25%) and those without. Although calprotectin declined in parallel with ANC, the correlation was only modest (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sub>s<\/jats:sub>\n                    : 0.20\u20130.53, all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). A sex\u2010, age\u2010 and risk group\u2010adjusted multivariable analysis showed significantly lower calprotectin levels in patients with BSI at days 1, 8 and 15 (all p\u2009&lt;\u20090.05). Each twofold decrease in calprotectin increased BSI risk with odds ratio (OR) 1.52 (1.07\u20132.15),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.018. In conclusion, reduced plasma calprotectin was associated with BSI during ALL induction therapy and may provide clinically relevant information beyond ANC to assess immunosuppression and guide antimicrobial strategies.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70393","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:12:43Z","timestamp":1772957563000},"page":"1339-1346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma calprotectin to assess susceptibility to bloodstream infections during paediatric acute lymphoblastic leukaemia induction treatment"],"prefix":"10.1111","volume":"208","author":[{"given":"Johanna V\u00e6vest Nymann","family":"Eriksen","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Institute for Inflammation Research, Centre for Rheumatology and Spine Disease Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"de Pietri","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7533-3112","authenticated-orcid":false,"given":"Mathias","family":"Rathe","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children's Hospital Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Hasle","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Enevold","sequence":"additional","affiliation":[{"name":"Institute for Inflammation Research, Centre for Rheumatology and Spine Disease Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7543-9016","authenticated-orcid":false,"given":"Claus H.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Institute for Inflammation Research, Centre for Rheumatology and Spine Disease Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0829-4993","authenticated-orcid":false,"given":"Kjeld","family":"Schmigelow","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Institute of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Moser","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Immunology and Microbiology Copenhagen University  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Institute for Inflammation Research, Centre for Rheumatology and Spine Disease Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Institute of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2364-4445","authenticated-orcid":false,"given":"Sarah","family":"Weischendorff","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Institute for Inflammation Research, Centre for Rheumatology and Spine Disease Rigshospitalet, Copenhagen University Hospital  Copenhagen 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