{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:06:21Z","timestamp":1784955981628,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    While bone\u2010modifying agents (BMAs) are well\u2010established components of frontline therapy in multiple myeloma, there are no data in the modern era to support their use in the relapsed setting. We conducted a retrospective analysis of US patients with relapsed\/refractory multiple myeloma (RRMM) diagnosed between 2014 and 2023. Progression\u2010free survival (PFS) and overall survival (OS) were analysed using Cox proportional hazards models adjusting for covariates including BMA receipt (BMA\u2010received) versus not (BMA\u2010deferred) at relapse. Of 1112 RRMM patients, 633 (56.9%) patients received BMAs following relapse. Compared to BMA\u2010received patients, BMA\u2010deferred patients had slightly worsened renal function and were less likely to have received BMAs during frontline therapy. There were no differences in PFS between groups: median PFS 10.1\u2009months (95% confidence interval [CI] 8.9\u201311.8\u2009months) for BMA\u2010deferred patients versus 9.2\u2009months (95% CI 7.7\u201311.3\u2009months;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.08) for BMA\u2010received patients. There were no differences in OS: median OS 39.6\u2009months (95% CI 33.9\u201358.1\u2009months) for BMA\u2010deferred patients versus 51.5\u2009months (95% CI 41.8\u201360.1\u2009months;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.10) for BMA\u2010received patients. Given the lack of clear benefit to BMA in the modern era, our data support future investigations to better personalize decision\u2010making around BMA resumption in RRMM.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70395","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:25:12Z","timestamp":1772997912000},"page":"1324-1330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Resumption of bone\u2010modifying agents in relapsed multiple myeloma does not improve outcomes: A real\u2010world analysis"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6496-3349","authenticated-orcid":false,"given":"Malcolm","family":"Su","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Texas Southwestern  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeel M.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Texas Southwestern  Dallas Texas USA"},{"name":"Myeloma, Waldenstrom's, and Amyloidosis Program, Simmons Comprehensive Cancer Center UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Cowan","sequence":"additional","affiliation":[{"name":"Clinical Research Division Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Larry D.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Texas Southwestern  Dallas Texas USA"},{"name":"Myeloma, Waldenstrom's, and Amyloidosis Program, Simmons Comprehensive Cancer Center UT Southwestern Medical Center  Dallas Texas 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