{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:54:28Z","timestamp":1781528068030,"version":"3.54.1"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Cerebrovascular accidents are serious complications of sickle cell disease (SCD). Children with abnormal transcranial Doppler (TCD) readings are at higher risk for stroke, and those with prior strokes have increased risk of recurrence. Chronic blood transfusion therapy (BTT) is the standard treatment for stroke prevention; hydroxyurea (hydroxycarbamide [HU]), a recommended alternative, is less effective. This study explores the use of modified short BTT combined with HU for stroke prevention in SCD. We reviewed medical records of 170 children (ages 2\u201316) with abnormal TCD or prior stroke treated with monthly BTT for 6\u20138\u2009months and HU. TCD results and stroke incidence were assessed 1\u2009year after discontinuing BTT. Among the children, 136 (80%) had abnormal TCD, 15 (11.2%) had current stroke and 19 (8.8%) had prior stroke. After discontinuation of BTT, abnormal TCD readings decreased significantly to 18.7% and 16.9% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05); those with normal TCD increased significantly from 38.8% to 52.8% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) after 1\u2009year. TCD velocity decreased significantly during the same period (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Only 2 (1.5%) children with abnormal TCD experienced stroke. Overall, 13 (7.8%) had stroke by 1\u2010year post BTT. In conclusion, the combination of short\u2010course BTT and HU significantly reduced stroke risk and incidence of stroke in children with SCD.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70399","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T06:23:43Z","timestamp":1775456623000},"page":"2194-2202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Short\u2010course blood transfusion therapy with hydroxyurea, a functional strategy in the management of stroke in children with sickle cell disease"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0343-1212","authenticated-orcid":false,"given":"Edamisan","family":"Temiye","sequence":"first","affiliation":[{"name":"Department of Paediatrics College of Medicine, University of Lagos  Idi\u2010Araba Lagos State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeseye","family":"Akinsete","sequence":"additional","affiliation":[{"name":"Department of Paediatrics College of Medicine, University of Lagos  Idi\u2010Araba Lagos State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adetokunbo","family":"Joacquim","sequence":"additional","affiliation":[{"name":"East and North HertfordshireTrust East of England Deanery  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4206-4681","authenticated-orcid":false,"given":"Ugonna","family":"Fakile","sequence":"additional","affiliation":[{"name":"East and North HertfordshireTrust East of England Deanery  Stevenage UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Ashefor","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Lagos University Teaching Hospital  Idi\u2010Araba Lagos State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3778-311X","authenticated-orcid":false,"given":"Chibuzor","family":"Ogamba","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Lagos University Teaching Hospital  Idi\u2010Araba Lagos State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Ogbenna","sequence":"additional","affiliation":[{"name":"Department of Haematology &amp; Blood Transfusion College of Medicine, University of Lagos  Idi\u2010Araba Lagos State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimota","family":"Adeyemo","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Lagos University Teaching Hospital  Idi\u2010Araba Lagos State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oladunni","family":"Okodugha","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Lagos University Teaching Hospital  Idi\u2010Araba Lagos State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehiosu","family":"Edokpolo","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Lagos University Teaching Hospital  Idi\u2010Araba Lagos State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaide","family":"Elemo","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Lagos University Teaching Hospital  Idi\u2010Araba Lagos State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abideen","family":"Salako","sequence":"additional","affiliation":[{"name":"Nigerian Institute of Medical Research  Yaba Lagos State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61229-X"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2015.11.005"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.09.013"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/193252"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001484"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24986"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10739680490278600"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-272682"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050460"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370216636722"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v14i2.22"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200606"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202273260905"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420505"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807023390102"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050460"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.122498"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-261123"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505183322001"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60355-3"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-146852"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2704"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-057893"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25529"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17698"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27252"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01041-7"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-702324"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25900"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(21)00368\u20109"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016620"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(22)00405\u20107"},{"issue":"1","key":"e_1_2_12_34_1","first-page":"26","article-title":"Experience with hydroxycarbamide use; 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