{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T09:00:17Z","timestamp":1780909217566,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>This study evaluated the cost\u2010effectiveness of blinatumomab for adult Philadelphia chromosome\u2010negative (Ph\u2010negative) patients with B\u2010cell acute lymphoblastic leukaemia (B\u2010ALL) who were in measurable residual disease (MRD)\u2010negative first remission, according to the ECOG1910 trial. A Markov model was created to compare the cost\u2010effectiveness of four cycles of blinatumomab alternating with chemotherapy versus standard\u2010of\u2010care chemotherapy (SOC), in both Japan and the United States. The analysis was conducted over a lifetime horizon. Incremental cost\u2010effectiveness ratios (ICERs) were calculated, with willingness\u2010to\u2010pay (WTP) thresholds set at \u00a57\u2009500\u2009000 in Japan and $150\u2009000 in the United States. A discount rate was set at 3%. In Japan, blinatumomab led to incremental costs of \u00a527\u2009472\u2009739 and yielded 3.82 quality\u2010adjusted life years (QALYs), resulting in an ICER of \u00a57\u2009193\u2009601 per QALY. In the United States, incremental costs were $463\u2009539 with 3.45 QALYs, yielding an ICER of $134\u2009298 per QALY. When the 3\u2010year progression\u2010free survival (PFS) with blinatumomab was assumed as 80%, it was cost\u2010effective unless the 3\u2010year PFS for SOC exceeded 64.9% in Japan and 65.6% in the United States. Blinatumomab was less cost\u2010effective for patients older than 51.6\u2009years in Japan and 55.6\u2009years in the United States. Blinatumomab is cost\u2010effective as consolidation therapy for MRD\u2010negative Ph\u2010negative B\u2010ALL patients, with sensitivity to age and PFS gains.<\/jats:p>","DOI":"10.1111\/bjh.70400","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:36:58Z","timestamp":1772991418000},"page":"1679-1691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost\u2010effectiveness of blinatumomab as post\u2010remission therapy in adults with measurable residual disease\u2010negative, Philadelphia chromosome\u2010negative B\u2010cell acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5333-8414","authenticated-orcid":false,"given":"Chihiro","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Medicine Jichi Medical University  Shimotsuke 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