{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:45:27Z","timestamp":1792043127366,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Genomic technologies including next\u2010generation sequencing (NGS) and arrays for cytogenetic anomalies are now standard of care in England for the diagnostic evaluation of patients with suspected haematological malignancies. Challenges remain in the management of potential germline findings as a result of NGS panels and copy number variant analyses in haemato\u2010oncology pathways. The first national consensus meeting in April 2022 organised by the\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.ukcgg.org\/information-education\/ukcgg-consensus-meetings\/\">UK Cancer Genetics Group (UKCGGG<\/jats:ext-link>\n                    ), in collaboration with the\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.cangene-canvaruk.org\/\">CanGene\u2010CanVar research programme<\/jats:ext-link>\n                    and the NHS England haemato\u2010oncology working group led to published best practice recommendations on laboratory and clinical pathways where there was potential to identify germline predisposition to haematological malignancies. On 3 and 4 April 2025, a second national meeting was held to address further challenges in these pathways and review updates in the national landscape subsequent to the 2022 recommendations. The meeting specifically focussed on\n                    <jats:italic>TP53<\/jats:italic>\n                    ,\n                    <jats:italic>DDX41<\/jats:italic>\n                    , myeloproliferative neoplasm driver genes, non\u2010single nucleotide variation and identification of gene carriers for addition to the National Inherited Cancer Predisposition Register (NICPR) through the National Disease Registration Service (NDRS). Using the format of a pre\u2010workshop survey followed by structured discussion and in\u2010meeting polling, high\u2010level consensus was achieved for UK best practice across these areas.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70404","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:01:23Z","timestamp":1772989283000},"page":"1211-1222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Somatic and germline genetic testing pathways in haematological malignancies: Best practice consensus guidelines from the 2025 national meeting organised by\n                    <scp>UK<\/scp>\n                    Cancer Genetics Group (\n                    <scp>UKCGG<\/scp>\n                    ),\n                    <scp>CanGene<\/scp>\n                    \u2010\n                    <scp>CanVar<\/scp>\n                    and the\n                    <scp>NHS<\/scp>\n                    England Haematological Oncology Working Group"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5170-0929","authenticated-orcid":false,"given":"B.","family":"Speight","sequence":"first","affiliation":[{"name":"East Anglian Medical Genetics Service, Cambridge Biomedical Campus, Cambridge University Hospitals NHS Foundation Trust  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hamblin","sequence":"additional","affiliation":[{"name":"Oxford University Hospitals NHS Foundation Trust &amp; Central &amp; South Genomic Laboratory Hub  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Talley","sequence":"additional","affiliation":[{"name":"HMDS, Leeds Teaching Hospitals Trust, St James's University Hospital  Leeds UK"},{"name":"Genomics Unit, NHS UK  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Tsoulaki","sequence":"additional","affiliation":[{"name":"Manchester Centre for Genomic Medicine, St Mary's Hospital  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Robinson","sequence":"additional","affiliation":[{"name":"North East and Yorkshire Genomics Laboratory Hub, St James's University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Dean","sequence":"additional","affiliation":[{"name":"HMDS, Leeds Teaching Hospitals Trust, St James's University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Khorashad","sequence":"additional","affiliation":[{"name":"The Royal Marsden NHS Foundation Trust  Sutton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3180-3570","authenticated-orcid":false,"given":"A.","family":"Kulasekararaj","sequence":"additional","affiliation":[{"name":"King's College Hospital NHS Foundation Trust  London UK"},{"name":"National Institute for Health and Care Research and Wellcome King's Research Facility  London UK"},{"name":"King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1955-9499","authenticated-orcid":false,"given":"A. L.","family":"Godfrey","sequence":"additional","affiliation":[{"name":"Haematopathology &amp; Oncology Diagnostics Service Cambridge University Hospitals NHS Foundation Trust  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Mead","sequence":"additional","affiliation":[{"name":"Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) and NIHR Biomedical Research Centre, University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9201-9216","authenticated-orcid":false,"given":"T. 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