{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:01:24Z","timestamp":1781305284421,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The modern management of chronic myeloid leukaemia (CML) identifies a new therapeutic goal of treatment\u2010free remission (TFR). Half of CML patients in durable deep molecular response (DMR) (MR\n                    <jats:sup>4<\/jats:sup>\n                    or better) can remain off tyrosine kinase inhibitors (TKIs) without experiencing loss of major molecular response. Despite a large number of TFR studies to date, there are no consistent predictors of successful TFR. We conducted a single\u2010centre cohort study on 197 patients discontinuing TKIs in DMR \u22651\u2009year and TKI therapy \u22653\u2009years. After TKI discontinuation, 98 patients (49.7%) lost MR\n                    <jats:sup>4<\/jats:sup>\n                    ; of these, 90 (91.8%; and 45.7% of the whole cohort) lost major molecular response (MMR or MR\n                    <jats:sup>3<\/jats:sup>\n                    ) after a median of 3.8\u2009months (1\u201393.3). The 2\u2010year probability of TFR (pTFR) was 57.7%. In multivariable analysis, male sex, age at diagnosis &gt;40\u2009years, faster achievement of MR\n                    <jats:sup>4<\/jats:sup>\n                    and longer duration of DMR were the only variables significantly associated with higher pTFR. Based on the multivariable analysis results, we built a TFR prognostic score (TPS) able to distinguish three groups with different 2\u2010year pTFR: good (89.9%), intermediate (61.2%) and poor (18.4%) TFR probability (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). We validated the TPS on an independent cohort of 91 patients. We propose that the TPS could become a useful guide for CML clinicians.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70409","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:44:45Z","timestamp":1773035085000},"page":"1660-1668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Introducing a prognostic score for successful treatment\u2010free remission in chronic myeloid leukaemia"],"prefix":"10.1111","volume":"208","author":[{"given":"Simone","family":"Claudiani","sequence":"first","affiliation":[{"name":"Department of Immunology and Inflammation, Faculty of Medicine Centre for Haematology, Imperial College London  London UK"},{"name":"Department of Haematology Hammersmith Hospital, Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Metelli","sequence":"additional","affiliation":[{"name":"Centre of Research in Epidemiology and Statistics (CRESS) University of Paris, INSERM, INRA  Paris France"},{"name":"Assistance Publique\u2014H\u00f4pitaux de Paris (APHP)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afzal","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Haematology Hammersmith Hospital, Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Hannah","sequence":"additional","affiliation":[{"name":"Department of Haematology King's College Hospital, King's College Hospital NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Byrne","sequence":"additional","affiliation":[{"name":"Centre for Clinical Haematology Nottingham University Hospitals NHS Trust  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Gallipoli","sequence":"additional","affiliation":[{"name":"Wellcome\u2010MRC Cambridge Stem Cell Institute  Cambridge UK"},{"name":"Department of Haematology Addenbrooke's Hospital, Cambridge University Hospitals, NHS Foundation Trust  Cambridge UK"},{"name":"Addenbrookes Hospital  Cambridge UK"},{"name":"Centre for Haematology Barts Cancer Institute, Queen Mary University of London  London UK"},{"name":"Barts Health NHS Trust  Barts UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Bulley","sequence":"additional","affiliation":[{"name":"Department of Haematology St James's University Hospital, Leeds Teaching Hospital NHS Trust  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian A.","family":"Horne","sequence":"additional","affiliation":[{"name":"Paul O'Gorman Leukaemia Research Centre, School of Cancer Sciences College of Medical, Veterinary and Life Sciences, University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Rothwell","sequence":"additional","affiliation":[{"name":"Department of Haematology St James's University Hospital, Leeds Teaching Hospital NHS Trust  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mhairi","family":"Copland","sequence":"additional","affiliation":[{"name":"Paul O'Gorman Leukaemia Research Centre, School of Cancer Sciences College of Medical, Veterinary and Life Sciences, University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Molecular &amp; Clinical Cancer Medicine University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Fernando","sequence":"additional","affiliation":[{"name":"Department of Immunology and Inflammation, Faculty of Medicine Centre for Haematology, Imperial College London  London UK"},{"name":"Department of Haematology Hammersmith Hospital, Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Innes","sequence":"additional","affiliation":[{"name":"Department of Immunology and Inflammation, Faculty of Medicine Centre for Haematology, Imperial College London  London UK"},{"name":"Department of Haematology Hammersmith Hospital, Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane F.","family":"Apperley","sequence":"additional","affiliation":[{"name":"Department of Immunology and Inflammation, Faculty of Medicine Centre for Haematology, Imperial College London  London UK"},{"name":"Department of Haematology Hammersmith Hospital, Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Milojkovic","sequence":"additional","affiliation":[{"name":"Department of Immunology and Inflammation, Faculty of Medicine Centre for Haematology, Imperial College London  London UK"},{"name":"Department of Haematology Hammersmith Hospital, Imperial College Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30192-X"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01647"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70233-3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.2914"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0264-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-742205"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2018.03.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24120"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1675879"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0776-2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16971"},{"key":"e_1_2_10_13_1","unstructured":"NCCN.Clinical practice guidelines in oncology (NCCN Guidelines\u00ae). 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