{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:37:03Z","timestamp":1791995823198,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The prognostic significance of impaired renal function in Waldenstr\u00f6m macroglobulinaemia (WM) remains poorly defined. We conducted a nationwide multicentre study to evaluate its clinical characteristics and prognostic impact in symptomatic patients. We analysed 402 symptomatic WM patients, stratified according to renal function at diagnosis (creatinine clearance &lt;60\u2009mL\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    ). Renal dysfunction was identified in 119 patients (29.6%). Renal biopsy was performed in 33 cases. Patients with reduced renal function were older (median age 76 vs. 67\u2009years,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), had lower haemoglobin levels (10.8 vs. 11.8\u2009g\/dL,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008) and higher 24\u2010h proteinuria (0.29 vs. 0.20\u2009g,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04). Comorbidities of renal interest were similarly distributed between groups. Renal dysfunction was associated with inferior median overall survival (139 vs. 203\u2009months,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and progression\u2010free survival (PFS) (80 vs. 106\u2009months,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002). Among patients aged &lt;70\u2009years, renal dysfunction remained associated with shorter PFS (77 vs. 121\u2009months,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005). Importantly, worsening renal function did not correlate with increasing age. In this setting, first\u2010line chemoimmunotherapy was associated with improved median PFS. Thus, renal dysfunction at diagnosis may represent an underrecognized, independent adverse prognostic factor in symptomatic WM.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70424","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:24:48Z","timestamp":1773030288000},"page":"2059-2068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Renal dysfunction in symptomatic Waldenstr\u00f6m macroglobulinaemia: A nationwide Italian multicentre study"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1352-306X","authenticated-orcid":false,"given":"Nicol\u00f2","family":"Danesin","sequence":"first","affiliation":[{"name":"Department of Medicine University of Padova, and Hematology Unit Azienda Ospedale Universit\u00e0 Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7868-7469","authenticated-orcid":false,"given":"Francesco","family":"Autore","sequence":"additional","affiliation":[{"name":"Policlinico Universitario A. Gemelli IRCCS Foundation  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2587-7901","authenticated-orcid":false,"given":"Anna Maria","family":"Frustaci","sequence":"additional","affiliation":[{"name":"Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmarco","family":"Favrin","sequence":"additional","affiliation":[{"name":"Division of Hematology Fondazione IRCSS San Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Cencini","sequence":"additional","affiliation":[{"name":"A.O.U. Senese and University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Noto","sequence":"additional","affiliation":[{"name":"Hematology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0873-1622","authenticated-orcid":false,"given":"Irene","family":"Dogliotti","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnologies and Health Sciences University of Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Olivieri","sequence":"additional","affiliation":[{"name":"Azienda Sanitaria Universitaria Integrata di Udine  Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Riva","sequence":"additional","affiliation":[{"name":"Azienda ULSS 8 Berica, Ospedale S. Bortolo  Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isacco","family":"Ferrarini","sequence":"additional","affiliation":[{"name":"Department of Engineering for Innovation Medicine, Section of Hematology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Barbui","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6314-0241","authenticated-orcid":false,"given":"Sara","family":"Steffanoni","sequence":"additional","affiliation":[{"name":"U.O.C. Ematologia, Ospedale Valduce  Como Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Marino","sequence":"additional","affiliation":[{"name":"Oncology 1 Unit, Veneto Institute of Oncology IOV\u2010IRCCS  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Puccini","sequence":"additional","affiliation":[{"name":"Department of Hematology AOU Careggi and University of Florence  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2937-851X","authenticated-orcid":false,"given":"Piero Maria","family":"Stefani","sequence":"additional","affiliation":[{"name":"Azienda ULSS 2 Marca Trevigiana, Ospedale Ca Foncello  Treviso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Rizzi","sequence":"additional","affiliation":[{"name":"Hematology and Transplant Unit, Department of Precision and Regenerative Medicine and Ionian Area University of Bari \u201cAldo Moro\u201d  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Merli","sequence":"additional","affiliation":[{"name":"Hematology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Ferrari","sequence":"additional","affiliation":[{"name":"University of Modena and Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8446-2285","authenticated-orcid":false,"given":"Stefano","family":"Luminari","sequence":"additional","affiliation":[{"name":"University of Modena and Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Visco","sequence":"additional","affiliation":[{"name":"Department of Engineering for Innovation Medicine, Section of Hematology University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livio","family":"Trentin","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Padova, and Hematology Unit Azienda Ospedale Universit\u00e0 Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Visentin","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Padova, and Hematology Unit Azienda Ospedale Universit\u00e0 Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annarita","family":"Conconi","sequence":"additional","affiliation":[{"name":"Division of Hematology Ospedale degli Infermi  Biella Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9711-1502","authenticated-orcid":false,"given":"Simone","family":"Ferrero","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnologies and Health Sciences University of Torino  Turin Italy"},{"name":"Hematology Division A.O.U. 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