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The primary end\u2010point 1\u2010year overall survival (OS) was 86% for RIC and 78% for MAC, meeting the pre\u2010specified targets for efficacy. At 4\u2009years, OS was 63% for RIC and 60% for MAC with low non\u2010relapse mortality of RIC 18% and MAC 4%. Engraftment was faster in the MAC arm (median time to neutrophil and platelet engraftment 11 and 15\u2009days; 21 and 24\u2009days in the RIC arm). The economic analysis showed that MAC had higher initial transplant costs, RIC incurred greater post\u2010transplant monitoring costs, resulting in higher overall costs (RIC \u00a3156\u2009711, MAC \u00a3131\u2009092). Quality of life (QoL)\u00a0outcomes in both indicated significant post\u2010transplant declines at 3\u2009months but returned to baseline by 12\u2009months. This study confirms the long\u2010term safety of using PBSC with PTCy in haploidentical transplants, with a good quality of life and reasonable costs.<\/jats:p>","DOI":"10.1111\/bjh.70429","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T05:52:02Z","timestamp":1774504322000},"page":"1758-1767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Results from the prospective phase 2 multicentre\n                    <scp>UK PBSC<\/scp>\n                    haplo trial using\n                    <scp>PTCy<\/scp>\n                    pre\u2010 or post\u2010stem cells"],"prefix":"10.1111","volume":"208","author":[{"given":"Hugues","family":"deLavallade","sequence":"first","affiliation":[{"name":"Department of Haematology Guys and St Thomas' NHS Foundation Trust  London UK"},{"name":"UCL Cancer Trials Centre Kings College Hospital NHS Foundation Trust  London UK"},{"name":"Department of 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