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Although patients often exhibit an initial favourable response to chemotherapy, with substantial clearance of tumour cells, most patients eventually relapse. This indicates the persistence of a chemoresistant ALL subpopulation capable of driving disease regeneration. Growing evidence implicates interactions between leukaemia cells and the bone marrow (BM) niche in this process. Our findings show that BM\u2010derived mesenchymal stem cells (MSCs) and adipocytes (BMAds) promote chemotherapy resistance in ALL cells via activation of the wingless\u2010related integration site (WNT) signalling pathway. Chemotherapy\u2010treated co\u2010cultures of MSCs\/BMAds and ALL cells exhibited upregulation of several WNT ligands in the stromal compartment. Notably, pharmacological inhibition of WNT signalling abrogated the stromal\u2010mediated chemoprotection and enhanced ALL cell apoptosis in\u00a0vitro. In\u00a0vivo, WNT inhibition in a\n                    <jats:italic>p185<\/jats:italic>\n                    <jats:sup>BCR\u2010ABL<\/jats:sup>\n                    <jats:italic>Arf<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    B\u2010ALL mouse model sensitised leukaemia cells to chemotherapy, delaying relapse and extending survival. Collectively, these results support the therapeutic potential of WNT inhibitors as a strategy to block the cross\u2010talk between the BM stroma and leukaemic cells and reduce ALL chemoresistance.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70431","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T12:42:18Z","timestamp":1773751338000},"page":"1572-1583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemotherapy\u2010driven expression of\n                    <scp>WNT<\/scp>\n                    ligands in bone marrow stromal cells contributes to chemoresistance in acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"208","author":[{"given":"Foteini","family":"Kalampalika","sequence":"first","affiliation":[{"name":"Centre for Haemato\u2010Oncology, Barts Cancer Institute Queen Mary University of London  London 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