{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:54:20Z","timestamp":1781528060664,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012100","name":"Associazione Italiana Contro le Leucemie-Linfomi e Mieloma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012100","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Mediastinal grey zone lymphoma (MGZL) is a rare disease with overlapping features between classical Hodgkin lymphoma (CHL) and primary mediastinal large B\u2010cell lymphoma (PMBL). The recent classifications limit the disease to mediastinal cases. Epstein\u2013Barr virus (EBV) is negative in most instances. Predominant resemblance to CHL (MGZL\u2010HL) or primary mediastinal B\u2010cell lymphoma (MGZL\u2010PMBL) can commonly be defined, although mixed features do occur. The morpho\u2010phenotypic heterogeneity of MGZL has significantly affected diagnostic reproducibility also among experts and the proposed diagnostic criteria turned out less concrete than for other lymphomas. Seventy GZL cases were collected from 14 Italian centres and slides reviewed by expert haematopathologists: 17 samples were confirmed according to current classification criteria, the residual being reclassified, mostly as CHL and PMBL, which well reflects the diagnostic challenge. By applying six B\u2010cell markers, MGZL\u2010HL commonly expressed \u22654 B\u2010antigens in \u226550% neoplastic cells at moderate\u2013strong intensity; MGZL\u2010PMBL expressed less B\u2010cell markers than expected (average 3.4 per case, in \u226550% neoplastic cells) at variable intensity. Overall, morphology, number of positive B\u2010cell markers, staining intensity and percentage of positive neoplastic cells are features that must be considered collectively, case by case, trying to adhere to the recent classification criteria, being aware that not all cases may easily be included.<\/jats:p>","DOI":"10.1111\/bjh.70432","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T03:21:23Z","timestamp":1773804083000},"page":"2016-2025","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mediastinal grey zone lymphomas: Results of the expert pathological review analysis of a case series enrolled in the multicentre\n                    <scp>BIOGZL<\/scp>\n                    \u20102020 study in Italy"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4136-3591","authenticated-orcid":false,"given":"Elena","family":"Sabattini","sequence":"first","affiliation":[{"name":"Haematopathology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Ascani","sequence":"additional","affiliation":[{"name":"Anatomic Pathology Unit, Azienda S. Maria University of Terni  Terni Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0223-8402","authenticated-orcid":false,"given":"Sabino","family":"Ciavarella","sequence":"additional","affiliation":[{"name":"Hematology and Cell Therapy Unit IRCCS Istituto Tumori \u2018Giovanni Paolo II\u2019  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Di Napoli","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Facchetti","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Molecular and Translational Medicine\u2010DMMT University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Lazzi","sequence":"additional","affiliation":[{"name":"Anatomic Pathology Unit, Department of Medical Biotechnology University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Leoncini","sequence":"additional","affiliation":[{"name":"Anatomic Pathology Unit, Department of Medical Biotechnology University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Lorenzi","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Molecular and Translational Medicine\u2010DMMT University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6244-3646","authenticated-orcid":false,"given":"Marco","family":"Lucioni","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, S.C. of Anatomic Pathology, Foundation IRCCS Policlinico San Matteo University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5593-5397","authenticated-orcid":false,"given":"Giovanna","family":"Motta","sequence":"additional","affiliation":[{"name":"Haematopathology Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Nassi","sequence":"additional","affiliation":[{"name":"Hematology Unit Careggi Hospital and University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Parisi","sequence":"additional","affiliation":[{"name":"Section of Pathology, Department of Diagnostics and Public Health Azienda Ospedaliera Universitaria Integrata Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Paulli","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, S.C. of Anatomic Pathology, Foundation IRCCS Policlinico San Matteo University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pileri","sequence":"additional","affiliation":[{"name":"Division of Haematopathology European Institute of Oncology IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurilio","family":"Ponzoni","sequence":"additional","affiliation":[{"name":"Pathology Unit, Hematopathology Diagnostic Area, Vita\u2010Salute San Raffaele University San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Tripodo","sequence":"additional","affiliation":[{"name":"IFOM ETS The AIRC Institute of Molecular Oncology  Milan 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