{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:54:19Z","timestamp":1781528059996,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018857","name":"International Myeloma Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Polyradiculoneuropathy, organomegaly, endocrinopathy, M\u2010protein and skin changes (POEMS) syndrome is a rare plasma cell dyscrasia. Questions remain regarding the use of induction therapy, given the known efficacy of melphalan autologous stem cell transplant (ASCT), as well as the optimal management of transplant\u2010ineligible patients. We describe the outcomes of 105 patients with POEMS syndrome and systemic disease, with a median follow\u2010up of 68\u2009months. Median age at diagnosis was 55\u2009years and 75 were male. Front\u2010line ASCT was performed in 67 patients, 61 melphalan 200\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    and six 140\u2009mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    . Upfront ASCT was delivered in 28 and 39 patients received prior induction. ASCT was highly efficacious, with a median overall survival (OS) not reached; 5\u2010 and 10\u2010year OS of 100% and 90.7%, respectively, with progression\u2010free survival (PFS) of 76.5% and 60.0%. No significant difference was seen in OS, PFS, depth of response or improvement in mobility status with induction therapy. Outcomes were inferior for non\u2010ASCT patients with a median OS of 11.4\u2009years, 5\u2010year OS of 72.8% and 10\u2010year OS of 64.7%. Median PFS for this cohort was 5.6\u2009years, with 5\u2010 and 10\u2010year PFS of 57.2% and 31.8% respectively. Attainment of complete vascular endothelial growth factor (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and\/or haematological response (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01) following front\u2010line therapy was associated with a lower risk of relapse.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70436","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T23:26:23Z","timestamp":1774308383000},"page":"2087-2095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Front\u2010line systemic treatment outcomes in\n                    <scp>POEMS<\/scp>\n                    syndrome"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1059-2906","authenticated-orcid":false,"given":"Oliver","family":"Tomkins","sequence":"first","affiliation":[{"name":"Department of Haematology University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4993-7828","authenticated-orcid":false,"given":"Jahanzaib","family":"Khwaja","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwen","family":"Koay","sequence":"additional","affiliation":[{"name":"Centre for Neuromuscular Disease, National Hospital for Neurology and Neurosurgery University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Japzon","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Keh","sequence":"additional","affiliation":[{"name":"Centre for Neuromuscular Disease, National Hospital for Neurology and Neurosurgery University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2102-6053","authenticated-orcid":false,"given":"Stephen","family":"Keddie","sequence":"additional","affiliation":[{"name":"Centre for Neuromuscular Disease, National Hospital for Neurology and Neurosurgery University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashu","family":"Wechalekar","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Kirkwood","sequence":"additional","affiliation":[{"name":"UCL Cancer Trials Centre University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisling","family":"Carr","sequence":"additional","affiliation":[{"name":"Centre for Neuromuscular Disease, National Hospital for Neurology and Neurosurgery University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3174-6027","authenticated-orcid":false,"given":"Michael","family":"Lunn","sequence":"additional","affiliation":[{"name":"Centre for Neuromuscular Disease, National Hospital for Neurology and Neurosurgery University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"D'Sa","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Sive","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2299"},{"issue":"11","key":"e_1_2_10_3_1","article-title":"Comprehensive diagnosis and management of POEMS syndrome","volume":"6","author":"D'Sa S","year":"2022","journal-title":"Hema"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009940"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001492"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09233-z"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008062"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27081"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2007.07.004"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-11-748855"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18400"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-07-795385"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.27"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16057"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2478"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.148460"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817249"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.081547"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02489-z"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204925"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70436","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70436","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:11:00Z","timestamp":1781525460000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/bjh.70436"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70436","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]},"assertion":[{"value":"2025-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}