{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:54:18Z","timestamp":1781528058849,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The clinical impact of immunosuppression termination (IST) after allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT) remains to be fully elucidated. This study was aimed at assessing the impact of IST within 2\u2009years after transplantation on subsequent clinical outcomes. We analysed data for patients from the Transplant Registry Unified Management Program 2 (TRUMP 2) database who survived without progression for at least 2\u2009years after allo\u2010HSCT. Of the 5061 patients whose median age was 48 (range: 0\u201379) years, 2320 discontinued immunosuppressive therapy within 2\u2009years (IST group), while 2741 did not (non\u2010IST group). The 4\u2010year overall survival (OS) rate was significantly higher in the IST group than in the non\u2010IST group (95.3% vs. 90.8%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). The 4\u2010year cumulative incidence of non\u2010relapse mortality (NRM) was significantly lower in the IST group than in the non\u2010IST group (3.5% vs. 8.6%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). This reduction in NRM was consistent across major causes, including graft\u2010versus\u2010host disease (GVHD)\u2010related mortality, infection\u2010related mortality and organ failure\u2010related mortality. Immunosuppressive therapy beyond 2\u2009years after allo\u2010HSCT was associated with inferior OS. Our findings suggest that the optimal transplant strategy is necessary to avoid long\u2010term immunosuppression for improving clinical outcomes in allo\u2010HSCT recipients.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70450","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T05:56:58Z","timestamp":1774245418000},"page":"2168-2174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Significant clinical impact of immunosuppressive therapy termination after allogeneic haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5118-7950","authenticated-orcid":false,"given":"Shigeo","family":"Fuji","sequence":"first","affiliation":[{"name":"Department of Hematology Osaka International Cancer Institute  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2410-9257","authenticated-orcid":false,"given":"Akihiro","family":"Ohmoto","sequence":"additional","affiliation":[{"name":"Advanced Medical Development Center Cancer Institute Hospital of Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8910-0021","authenticated-orcid":false,"given":"Yuho","family":"Najima","sequence":"additional","affiliation":[{"name":"Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Hematology Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatsugu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Hematology Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Hematology Hokkaido University Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo 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Department of Multidisciplinary Internal Medicine Tottori University  Tottori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moeko","family":"Hino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine Chiba University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Kanda","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Atsuta","sequence":"additional","affiliation":[{"name":"Japanese Data Center for Hematopoietic Cell Transplantation  Nagakute Japan"},{"name":"Department of Registry Science for Transplant and Cellular Therapy Aichi Medical University School of Medicine  Nagakute Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimikazu","family":"Yakushijin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology Kobe University Hospital  Kobe 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