{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:09:15Z","timestamp":1792372155416,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K11648"],"award-info":[{"award-number":["25K11648"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019356","name":"SGH Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT) offers a curative potential for myelodysplastic syndrome (MDS) and myelodysplastic\/myeloproliferative neoplasm (MDS\/MPN). We examined survival trends using a nationwide database of 7175 patients who underwent their first allo\u2010HSCT between 1998 and 2022. Overall mortality decreased over time in patients with early MDS (hazard ratio [HR] 0.79, 95% confidence interval [CI] 0.65\u20130.97,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026 in 2013\u20132017; HR 0.54, 95% CI 0.42\u20130.70,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001 in 2018\u20132022), advanced MDS (HR 0.80, 95% CI 0.71\u20130.90,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001 in 2013\u20132017; HR 0.74, 95% CI 0.65\u20130.85,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001 in 2018\u20132022), chronic myelomonocytic leukaemia (HR 0.45, 95% CI 0.32\u20130.64,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001 in 2013\u20132017; HR 0.53, 95% CI 0.37\u20130.74,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001 in 2018\u20132022) and atypical chronic myeloid leukaemia (HR 0.32, 95% CI 0.13\u20130.80,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.016 in 2013\u20132017; HR 0.26, 95% CI 0.10\u20130.68,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006 in 2018\u20132022). These decreases in overall mortality were mainly attributable to reductions in non\u2010relapse mortality. Meanwhile, no significant difference in overall mortality was observed in patients with MDS\/MPN\u2010unclassified and therapy\u2010related myeloid neoplasm. Across all disease subtypes, relapse incidence did not significantly decrease over time, highlighting persistent challenges in reducing the risk of post\u2010transplant relapse.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70463","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T05:47:32Z","timestamp":1775454452000},"page":"2143-2155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Trends in survival outcomes after allogeneic transplantation for\n                    <scp>MDS<\/scp>\n                    and\n                    <scp>MDS<\/scp>\n                    \/\n                    <scp>MPN<\/scp>\n                    in a real\u2010world experience: A 25\u2010year nationwide study"],"prefix":"10.1111","volume":"208","author":[{"given":"Hidehiro","family":"Itonaga","sequence":"first","affiliation":[{"name":"Transfusion and Cell Therapy Unit Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Hematology Nagasaki University Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Tachi","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Internal Medicine National Defense Medical College  Tokorozawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6426-6770","authenticated-orcid":false,"given":"Shuhei","family":"Kurosawa","sequence":"additional","affiliation":[{"name":"Division of Transfusion and Cell Therapy, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo 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Division, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Hematology Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Hematology Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Hematology Hiroshima Red Cross Hospital &amp; Atomic\u2010Bomb Survivors Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Asada","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine Keio University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Kurashiki Central Hospital  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Eto","sequence":"additional","affiliation":[{"name":"Department of Hematology Hamanomachi Hospital  Fukuoka 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