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The survival of patients with systemic amyloid light\u2010chain (AL) amyloidosis largely depends on the extent of end\u2010organ damage. Patients with early\u2010stage disease can expect approximately 80% survival at 5\u2009years with contemporary treatment, compared to less than 30% for those with advanced disease. The aim of this guideline is to facilitate recognition and raise suspicion of amyloidosis. It is important to recognise that amyloidosis can present in any clinic, including general medicine\/care of the elderly and general practice.<\/jats:p>","DOI":"10.1111\/bjh.70472","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T06:34:28Z","timestamp":1778222068000},"page":"1931-1938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early diagnosis of\n                    <scp>AL<\/scp>\n                    amyloidosis in haematology, cardiology, neurology, renal and general clinics: A British Society for Haematology Guideline"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3560-0132","authenticated-orcid":false,"given":"Mamta","family":"Garg","sequence":"first","affiliation":[{"name":"University Hospitals Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3281-9929","authenticated-orcid":false,"given":"Satarupa","family":"Choudhuri","sequence":"additional","affiliation":[{"name":"Northern Cancer Alliance NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9627-736X","authenticated-orcid":false,"given":"Christopher","family":"Parrish","sequence":"additional","affiliation":[{"name":"Leeds Institute of Clinical Trials Research University of Leeds and Leeds Teaching Hospitals NHS Trust  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Hawkins","sequence":"additional","affiliation":[{"name":"The Clatterbridge Cancer Centre NHS Foundation Trust  Birkenhead UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Lachmann","sequence":"additional","affiliation":[{"name":"National Amyloidosis Centre, Royal Free London NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Clayton","sequence":"additional","affiliation":[{"name":"University Hospitals Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Richardson","sequence":"additional","affiliation":[{"name":"Myeloma UK  Edinburgh UK"},{"name":"University Health Service  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1538-8485","authenticated-orcid":false,"given":"Y. 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