{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T09:00:20Z","timestamp":1780909220685,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"\n Pure red cell aplasia (PRCA) is increasingly recognised as a T\u2010cell\u2010mediated bone marrow failure syndrome, yet its immunogenetic drivers remain poorly defined. In their paper, Yamashita et\u00a0al. integrate human leucocyte antigen (HLA) typing, T\u2010cell receptor repertoire analysis and mutational profiling to reveal enriched HLA alleles,\n signal transducer and activator of transcription 3<\/jats:italic>\n (\n STAT3<\/jats:italic>\n )\u2010mutated T\u2010cell clones and a shared T cell receptor beta (TCR\u03b2) motif in PRCA patients. These findings suggest that antigen\u2010driven cytotoxic T\u2010cell responses represent a central mechanism underlying erythroid suppression.\n <\/jats:p>\n Commentary on: Yamashita et\u00a0al. Immunological features of acquired pure red cell aplasia: Specific human leucocyte antigen alleles, signal transducer and activator of transcription 3 mutations and a unique T\u2010 cell receptor beta motif. Br J Haematol 2026; 208:1797\u20131805.<\/jats:p>","DOI":"10.1111\/bjh.70473","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:05:58Z","timestamp":1775469958000},"page":"1887-1889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Decoding immune\u2010driven erythroid failure in pure red cell aplasia"],"prefix":"10.1111","volume":"208","author":[{"given":"Federico","family":"Spataro","sequence":"first","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area \u2010 DiMePRe\u2010J, Section of Pharmacology University of Bari Aldo Moro Bari Italy"},{"name":"Department of Precision and Regenerative Medicine and Ionian Area \u2010 DiMePRe\u2010J, Guido Baccelli Unit of Internal Medicine, School of Medicine University of Bari Aldo Moro Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Desantis","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area \u2010 DiMePRe\u2010J, Section of Pharmacology University of Bari Aldo Moro Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-9698","authenticated-orcid":false,"given":"Antonio Giovanni","family":"Solimando","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area \u2010 DiMePRe\u2010J, Guido Baccelli Unit of Internal Medicine, School of Medicine University of Bari Aldo Moro Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.70475"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-05-717140"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021010898"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111019"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911765"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-365189"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018022723"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-06-435297"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02539"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-023-01017-0"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70473","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T08:11:15Z","timestamp":1780906275000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,6]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/bjh.70473"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70473","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,6]]},"assertion":[{"value":"2026-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}