{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:54:34Z","timestamp":1781528074316,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Immune thrombocytopenia (ITP) is characterized by immune\u2010mediated platelet destruction and impaired platelet production. Both plasma\/B cell\u2010producing anti\u2010platelet autoantibodies and autoreactive T cells lead to thrombocytopenia and treatment refractoriness. Conventional treatments often fail to induce sustained remission off treatment (SROT). Chimeric antigen receptor (CAR) T cell therapy, developed for haematological malignancies, has recently been explored in autoimmunity to target plasma\/B cells, reducing autoantibody production. Early studies suggest potential for benefit in refractory autoimmune disease, including ITP. This nutshell review summarizes CAR T cell therapy in autoimmunity, especially refractory ITP.<\/jats:p>","DOI":"10.1111\/bjh.70482","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T11:51:07Z","timestamp":1776340267000},"page":"1928-1930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chimeric antigen receptor T cells for autoimmune diseases, in particular immune thrombocytopenia"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5851-6075","authenticated-orcid":false,"given":"Samuel P.","family":"Soff","sequence":"first","affiliation":[{"name":"Department of Medicine Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Ruder","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2884-9247","authenticated-orcid":false,"given":"James B.","family":"Bussel","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1810479"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01401-z"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.19462"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14161242"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2308917"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2403743"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2024.102137"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-024-02429-6"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18909"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.20061"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02504-2"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","unstructured":"ShuJ XuM XieW LiuL WeiQ LiH et\u00a0al.BCMA\u2010targeted CAR T cells for multi\u2010refractory primary immune thrombocytopenia: a pilot study.ASH annual meetingabstract publication 1267; 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