{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:24:53Z","timestamp":1791494693028,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","award":["R368\u2010A21409"],"award-info":[{"award-number":["R368\u2010A21409"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Mixed phenotype acute leukaemia (MPAL) is a rare subtype of acute leukaemia possessing significant therapeutic challenges, as no standardized, evidence\u2010based treatment regimen has been defined. In this nationwide study, we aimed to assess the effect of an acute lymphoid leukaemia (ALL)\u2010like regimen; an acute myeloid leukaemia (AML)\u2010like regimen; and a hybrid regimen on complete remission (CR), overall survival (OS) and event\u2010free survival (EFS). Patients were identified through the Danish National Pathology Registry and validated according to the 2022 WHO classification. OS was estimated using the Kaplan\u2013Meier estimator, and differences in OS were assessed with the log\u2010rank test. Inverse probability weighting was used to balance compared groups with respect to age and calendar year. Among the 43 intensively treated WHO 2022 MPAL patients, 25 (58.1%) received ALL regimens, 10 (23.3%) received AML regimens and 8 (18.6%) received hybrid regimens. CR rates by treatment regimen were highest for hybrid regimen (87.5% (95% confidence interval (CI): 47.3%\u201399.7)), followed by ALL regimen (72% (95% CI: 50.6%\u201387.5%)) and AML regimen (40% (95% CI: 12.2%\u201373.8%)). Treatment with hybrid regimens consisting of a fludarabine\u2010based approach (fludarabine, cytarabine, G\u2010CSF and idarubicin [FLAG\u2010IDA], fludarabine, cytarabine, G\u2010CSF and mitoxantrone [Mito\u2010FLAG]\u00a0or fludarabine, etoposide, G\u2010CSF, mitoxantrone and cytarabine [FLEGMA]) was associated with improved OS and EFS compared to a classic daunorubicin\u2013cytarabine AML regimen (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002 respectively).\n                  <\/jats:p>","DOI":"10.1111\/bjh.70491","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T08:48:56Z","timestamp":1776415736000},"page":"2104-2112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Improved survival with fludarabine\u2010based therapies in mixed phenotype acute leukaemia: A population\u2010based study using the\n                    <scp>WHO<\/scp>\n                    2022 classification"],"prefix":"10.1111","volume":"208","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8809-8000","authenticated-orcid":false,"given":"Lisa\u2010Maj","family":"Christensen","sequence":"first","affiliation":[{"name":"Department of Hematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1119-4782","authenticated-orcid":false,"given":"Mikkel Runason","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Mathemathical Sciences Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas Faartoft","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6753-7051","authenticated-orcid":false,"given":"Daniel Tuyet","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Haematology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Molecular Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Dybk\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1535-9601","authenticated-orcid":false,"given":"Kirsten","family":"Gr\u00f8nb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Haematology Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Biotech Research and Innovation Center (BRIC) University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarec Christoffer","family":"El\u2010Galaly","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"},{"name":"Department of Haematology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Molecular Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne Schmidt","family":"Ettrup","sequence":"additional","affiliation":[{"name":"Department of Pathology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Beier","family":"Ommen","sequence":"additional","affiliation":[{"name":"Department of Haematology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4537-2505","authenticated-orcid":false,"given":"Anne Louise T\u00f8lb\u00f8ll","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Haematology Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4478-1297","authenticated-orcid":false,"given":"Dennis Lund","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Haematology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne Tang","family":"Severinsen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"issue":"8","key":"e_1_2_10_3_1","article-title":"Mixed\u2010phenotype acute leukemia: clinical diagnosis and therapeutic strategies","volume":"10","author":"George BS","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32552"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V116.21.1683.1683"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","unstructured":"MatutesE PicklWF Van't VeerM MorillaR SwansburyJ StroblH et\u00a0al.Mixed\u2010phenotype acute leukemia: clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification.2011. 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