{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:13:36Z","timestamp":1783455216262,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>NUP98<\/jats:italic>\n                    rearrangements define a high\u2010risk, genetically heterogeneous subtype of paediatric acute myeloid leukaemia (AML), yet comprehensive clinicogenetic and survival data remain limited. This retrospective, single\u2010centre study of 32 paediatric patients (2017\u20132025) found a median age of 8.7\u2009years and predominance of the\n                    <jats:italic>NUP98::NSD1<\/jats:italic>\n                    fusion (68.8%), frequently co\u2010mutated with\n                    <jats:italic>FLT3<\/jats:italic>\n                    \u2010ITD (50%) and\n                    <jats:italic>WT1<\/jats:italic>\n                    (43.8%). Complete remission (CR) rates increased from 53.1% to 87.5% after first and second induction. With a median follow\u2010up of 41.7\u2009months, the estimated 3\u2010year overall survival (OS), event\u2010free survival (EFS) and cumulative incidence of relapse (CIR) were 81.2% (95% confidence interval [CI], 65.9%\u201396.5%), 62.8% (95% CI, 43.8%\u201381.8%) and 28.1% (95% CI, 12.9%\u201345.6%), respectively; corresponding rates among the 29 transplanted patients were 79.8% (95% CI, 63.5%\u201396.1%), 68.7% (95% CI, 50.3%\u201387.1%) and 26.0% (95% CI, 11.1%\u201343.9%) respectively. Exploratory multivariate analysis identified failure to achieve CR after induction 2 as a risk factor for OS,\n                    <jats:italic>WT1<\/jats:italic>\n                    mutation for relapse in the entire cohort and pretransplant minimal residual disease (MRD) positivity for relapse in the transplant subgroup. This confirms that\n                    <jats:italic>NUP98<\/jats:italic>\n                    \u2010rearranged AML necessitates intensive therapy including transplant and highlights\n                    <jats:italic>WT1<\/jats:italic>\n                    and pretransplant MRD as key prognostic markers for risk\u2010adapted strategies.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70497","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:20:16Z","timestamp":1777375216000},"page":"172-179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicogenetic characteristics and outcomes of children with\n                    <i>NUP98<\/i>\n                    \u2010rearranged acute myeloid leukaemia: A single\u2010centre cohort study of 32 cases"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0051-2095","authenticated-orcid":false,"given":"Zhi\u2010xiao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Peking University People's Hospital Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Peking University People's Hospital Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai\u2010dong","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Peking University People's Hospital Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le\u2010ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Peking University People's Hospital Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2010ping","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Peking University People's Hospital Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010min","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Peking University People's Hospital Peking University  Beijing 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