{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:10:32Z","timestamp":1789193432384,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Sickle cell disease (SCD), a prevalent inherited non\u2010communicable disease, remains a neglected public health priority, especially children and adolescents in many low\u2010 and middle\u2010income countries. The global burden of SCD in youth remains under\u2010characterized given fragmented data and disparities in diagnostics. This study aims to conduct a systematic review and meta\u2010analysis quantifying the global prevalence and cause\u2010specific mortality of SCD in individuals aged under\u20105 and under\u201020. A search was conducted to identify studies reporting SCD prevalence or mortality published between 2017 and 2023. Eligible studies were assessed for quality and random\u2010effects meta\u2010analyses generated pooled estimates, stratified by age group, study design and United Nations country group classification. Fifty\u2010seven studies were included, encompassing data from over 3.6 million individuals and 56\u2009593 recorded deaths. Among children under\u20105, the prevalence was 0.008 (95% confidence interval [CI]: 0.004\u20130.016). The global under\u201020 population\u2010based prevalence of SCD was 0.009 (95% CI: 0.005\u20130.017). The global under\u201020 cause\u2010specific mortality proportion was 0.029 (95% CI: 0.001\u20130.621), with under\u20105 and 5\u201319\u2009years of age mortality proportions estimated at 0.021 and 0.017, respectively. This first global synthesis of under\u20105s and under\u201020s demonstrates substantial paediatric burden but is constrained by extreme heterogeneity, wide uncertainty and incomplete geographic coverage, underscoring the urgency for improved screening, surveillance and cause\u2010of\u2010death attribution to support accurate global burden estimation of SCD.<\/jats:p>","DOI":"10.1111\/bjh.70501","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:26:19Z","timestamp":1777854379000},"page":"887-899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Contemporary global burden of sickle cell anaemia under\u20105 and under\u201020: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1080-6786","authenticated-orcid":false,"given":"Kelly","family":"Pimenta","sequence":"first","affiliation":[{"name":"Department of Global Pediatric Medicine St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of Memphis  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abu Mohd","family":"Naser","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of Memphis  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Price","sequence":"additional","affiliation":[{"name":"Albert S. Cook Library, Towson University  Towson Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ombeni","family":"Idassi","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Strong","sequence":"additional","affiliation":[{"name":"Department of Maternal, Newborn, Child and Adolescent Health and Ageing World Health Organization  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Were","sequence":"additional","affiliation":[{"name":"Department of Maternal, Newborn, Child and Adolescent Health and Ageing World Health Organization  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8131-7728","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric B.","family":"Piel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics School of Public Health, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane S.","family":"Hankins","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Smeltzer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of Memphis  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(23)00118\u20107"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.10"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.378"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666\u20107568(21)00115\u2010X"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2019.002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25305"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/1518\u20108345.2885.3074"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3511"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","DOI":"10.5089\/9781455216789.001","volume-title":"Classifications of countries Basedon their level of development: how it is done and how it could Be done","author":"Nielsen L","year":"2011"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.09.013"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.08.021103"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2008.04.007"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2024.101678"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20485"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2021\u2010005806"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.40599"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00038"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(21)00515\u20105"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/003335491312800206"},{"key":"e_1_2_9_22_1","volume-title":"Reference library of selected materials: IMCI integrated Management of Childhood Illness","author":"World Health O, United Nations Children's F","year":"2001"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010025\u201003029\u20101"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(20)30229\u20101"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(20)30204\u20100"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70501","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70501","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:04:01Z","timestamp":1789193041000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,3]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/bjh.70501"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70501","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,3]]},"assertion":[{"value":"2025-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}