{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:14:36Z","timestamp":1783455276786,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Chimeric antigen receptor T cells directed against CD\u201019 are highly effective therapies for various subtypes of B\u2010cell non\u2010Hodgkin lymphoma (NHL). We have studied the impact of patient\u2010specific lymphocyte growth kinetics after lymphoid depletion chemotherapy on both long\u2010term outcomes and toxicity in patients with diffuse large B\u2010cell non\u2010Hodgkin lymphoma (DLBCL). The growth of the lymphocyte populations early after chimeric antigen receptor T\u2010cell (CAR\u2010T) therapy is well described by an exponential function and the growth rate of the cells appears to be one of the most critical determinants of overall survival in these patients. The maximum lymphocyte peak and the area under curve for lymphocytes within the first 4\u2009weeks after CAR\u2010T therapy had no impact on survival. Receiver operator characteristic analysis determined that a replication rate \u22650.3876\/day is associated with superior rates of complete response and durable responses. This threshold is associated with higher grades of cytokine release syndrome and the need for tocilizumab. However, patients with this threshold have a median overall survival of 3.04\u2009years compared to 1.035\u2009years for patients with slower lymphocyte replication (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0206). The major determinant of depth of response and durability of response to CAR\u2010T in NHL is the speed of lymphocyte expansion.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70502","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T08:20:32Z","timestamp":1776759632000},"page":"189-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lymphocyte dynamics after\n                    <scp>CAR<\/scp>\n                    \u2010T therapy for non\u2010Hodgkin lymphoma"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9308-7145","authenticated-orcid":false,"given":"Sarah","family":"Dingli","sequence":"first","affiliation":[{"name":"Earl E. Bakken Medical Devices Center, Department of Mechanical Engineering, College of Science and Engineering University of Minnesota  Twin Cities Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7811-6332","authenticated-orcid":false,"given":"Paul","family":"Rothweiler","sequence":"additional","affiliation":[{"name":"Earl E. Bakken Medical Devices Center, Department of Mechanical Engineering, College of Science and Engineering University of Minnesota  Twin Cities Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre De Menezes Silva","family":"Corraes","sequence":"additional","affiliation":[{"name":"Division of Hematology and Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3380-5326","authenticated-orcid":false,"given":"Albert","family":"Atallah\u2010Yunes","sequence":"additional","affiliation":[{"name":"Division of Hematology and Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1244-6758","authenticated-orcid":false,"given":"Stephen M.","family":"Ansell","sequence":"additional","affiliation":[{"name":"Division of Hematology and Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Nora","family":"Bennani","sequence":"additional","affiliation":[{"name":"Division of Hematology and Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1860-2424","authenticated-orcid":false,"given":"Urshila","family":"Durani","sequence":"additional","affiliation":[{"name":"Division of Hematology and Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick B.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Division of Hematology and Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arushi","family":"Khurana","sequence":"additional","affiliation":[{"name":"Division of Hematology and Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Paludo","sequence":"additional","affiliation":[{"name":"Division of Hematology and Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. C. Villasboas","family":"Bisneto","sequence":"additional","affiliation":[{"name":"Division of Hematology and Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1576-8341","authenticated-orcid":false,"given":"Yucai","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Hematology and Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Hematology and Department of Internal Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0385-4023","authenticated-orcid":false,"given":"Arthur G.","family":"Erdman","sequence":"additional","affiliation":[{"name":"Earl E. 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