{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T02:30:10Z","timestamp":1787797810662,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    This prospective study evaluated the incidence and dynamics of frailty in 156 adults with lymphoproliferative syndromes undergoing autologous haematopoietic stem cell transplantation (HSCT). Frailty was assessed using the haematopoietic cell transplantation (HCT) frailty scale in patients from 15 Spanish institutions at initial consultation, transplant admission and day +100. Quality of life (QoL) was measured using the EuroQoL. At first consultation, 45 patients (28.8%) were classified as fit, 93 (59.6%) as pre\u2010frail and 18 (11.6%) as frail. Frailty was more frequent among older patients, those with Karnofsky performance status (KPS) below 90%, and abnormal Mini\u2010Cog scores (&lt;3). Rates of relapse, death, readmission and median hospital stay were similar across frailty groups. However, frail patients reported significantly worse QoL. One\u2010year non\u2010relapse mortality was higher in frail patients than in pre\u2010frail and fit patients, although differences were not statistically significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.19). At day +100, 33.6% of patients were fit, 57.9% pre\u2010frail and 8.5% frail, demonstrating significant transitions in frailty over time (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). Moreover, frail patients showed lower relapse\u2010free [53.3% (17.7\u201379.6) vs. 85.3% (68.3\u201393.6),\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.05] and overall survival [77.8% (36.5\u201393.9) vs. 100%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.16], and worse perceived QoL than fit ones. Overall, frailty was dynamic and clinically relevant, supporting routine assessment and targeted interventions to mitigate adverse outcomes.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70505","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:40:39Z","timestamp":1777516839000},"page":"197-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prospective implementation of the HCT frailty scale in adults with lymphoproliferative syndromes candidates for autologous haematopoietic stem cell transplantation: Results from a multicentre GETH\u2010TC study"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0737-4211","authenticated-orcid":false,"given":"Javier","family":"Cornago","sequence":"first","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Instituto Investigaci\u00f3n Sanitaria FJD  Madrid Spain"},{"name":"Universidad Aut\u00f3noma de Madrid (UAM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Baile","sequence":"additional","affiliation":[{"name":"Complejo Asistencial Universitario de Salamanca\/IBSAL  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Acera","sequence":"additional","affiliation":[{"name":"Complejo Asistencial Universitario de Salamanca\/IBSAL  Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fox","sequence":"additional","affiliation":[{"name":"Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"del Mar P\u00e9rez\u2010Artigas","sequence":"additional","affiliation":[{"name":"Hospital Universitari Vall d'Hebron  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Santamar\u00eda","sequence":"additional","affiliation":[{"name":"Hospital \u00c1lvaro Cunqueiro  Vigo, Pontevedra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"del Carmen Quintela","sequence":"additional","affiliation":[{"name":"Hospital \u00c1lvaro Cunqueiro  Vigo, Pontevedra Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"S\u00e1nchez\u2010Salinas","sequence":"additional","affiliation":[{"name":"H.C.U. Virgen de la Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquina M.","family":"Salmer\u00f3n","sequence":"additional","affiliation":[{"name":"H.C.U. Virgen de la Arrixaca  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Illana","sequence":"additional","affiliation":[{"name":"Hospital Universitario de la Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Abdallahi\u2010Lefdil","sequence":"additional","affiliation":[{"name":"Hospital Universitario de la Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pardo","sequence":"additional","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Instituto Investigaci\u00f3n Sanitaria FJD  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sol\u00e1n","sequence":"additional","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Instituto Investigaci\u00f3n Sanitaria FJD  Madrid 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Beorlegui\u2010Murillo","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Universidad de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Molina","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Esquirol","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3599-4901","authenticated-orcid":false,"given":"Isabel","family":"Izquierdo","sequence":"additional","affiliation":[{"name":"Hospital Miguel Servet  Zaragoza 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