{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T04:13:32Z","timestamp":1787285612106,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    This UK\u2010based retrospective analysis describes real\u2010world treatment patterns and outcomes in 175 patients with accelerated (AP,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200969) or blast\u2010phase (BP,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009106) \u2018Philadelphia\u2010negative\u2019 myeloproliferative neoplasms (MPN\u2010AP\/BP) diagnosed between 2013 and 2025. Median age at transformation was 71\u2009years. With a median follow\u2010up of 45.2\u2009months, median overall survival (OS) was 14.9\u2009months, significantly worse for MPN\u2010BP (6.7\u2009months) versus MPN\u2010AP (25.3\u2009months). Treatment selection was heterogeneous across centres. Intensive chemotherapy (IC) improved outcomes only when followed by allogeneic haematopoietic stem cell transplant (allo\u2010HSCT) (median OS 24.7\u2009months). Ruxolitinib\u2010based regimens, particularly combined with azacitidine, showed acceptable activity in AP (median OS 27.2\u2009months). Venetoclax\u2010based regimens achieved a median OS of 14.9\u2009months across the cohort. Multivariable analysis identified IC and venetoclax\u2010based therapy as independently associated with better outcomes, reflecting patient selection, while\n                    <jats:italic>TP53<\/jats:italic>\n                    mutations predicted inferior survival. IC carried high rates of febrile neutropenia and sepsis; venetoclax was associated with prolonged cytopenias. This study confirms the poor prognosis of MPN\u2010AP\/BP, the absence of a unified UK consensus approach and the need for improved therapies and prospective studies to determine optimal treatment approaches for this challenging cohort.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70511","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:02:58Z","timestamp":1777852978000},"page":"160-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010world treatment patterns and outcomes in accelerated and blast\u2010phase myeloproliferative neoplasms: Insights from a large multi\u2010centre cohort analysis in the United Kingdom"],"prefix":"10.1111","volume":"209","author":[{"given":"Alexandros","family":"Rampotas","sequence":"first","affiliation":[{"name":"University College London Hospitals NHS Foundation Trust  London 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