{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:54:34Z","timestamp":1781528074219,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>A better understanding of factors influencing red blood cell (RBC) alloimmunization is desirable, given the dangers of this non\u2010infectious serious hazard of transfusion. In a case\u2013control retrospective study utilizing the Recipient Epidemiology and Donor Evaluation study (REDS)\u2010III Biological Specimen and Data Repository Information Coordinating Center (BioLINCC) dataset, we investigated blood donor, component and recipient variables associated with RBC alloantibody specificities. 19\u2009697 controls with no new alloantibody detected 2\u201316\u2009weeks post\u2010transfusion and 861 cases (with antibodies including anti\u2010E, \u2010K, \u2010Jka, \u2010C and \u2010c) were studied. Univariate comparison revealed multiple factors are found more frequently in alloimmunized cases than controls, including use of ABO non\u2010identical units, recipient female gender and shorter RBC unit storage duration. Multivariate donor\/component odds ratio for each antibody specificity revealed myelodysplastic syndrome (MDS), sickle cell disease, rheumatoid arthritis and lupus as being associated with higher odds of antibody formation, with MDS being associated with the most antibody specificities. ABO non\u2010identical recipient\u2013donor pairs were associated with higher odds of alloimmunization for all antibody specificities evaluated. RBC storage duration showed significance only for anti\u2010E after multivariable analysis, with units stored for a longer duration (&gt;12\u2009days) associated with reduced odds of alloimmunization. In sum, blood donor, recipient and component elements variably impacted alloantibody formation in transfusion recipients, with differences observed by antibody specificity.<\/jats:p>","DOI":"10.1111\/bjh.70536","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:20:31Z","timestamp":1778718031000},"page":"2212-2221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of blood donor, component and recipient variables on antigen\u2010specific alloantibodies"],"prefix":"10.1111","volume":"208","author":[{"given":"Duan","family":"Wang","sequence":"first","affiliation":[{"name":"North Carolina School of Science and Mathematics  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingbo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7928-3132","authenticated-orcid":false,"given":"Jeanne E.","family":"Hendrickson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Pathology and Laboratory Medicine Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7533-6842","authenticated-orcid":false,"given":"Matthew S.","family":"Karafin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Lab Medicine University of North Carolina School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-08-833962"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15182"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12940"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022006982"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17966"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13379"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-490623"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1995.35795357881.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.215087"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700401"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00946.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13123"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.11.028"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008647"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2022.12.009"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02481.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17251"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjhh.2015.07.003"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP2J8SVWOXRLRB"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12156"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24051"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18135"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.1996.7140216.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001143"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19837"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12455"},{"issue":"1","key":"e_1_2_11_28_1","first-page":"53","article-title":"Molecular matching for Rh and K reduces red blood cell alloimmunisation in patients with myelodysplastic syndrome","volume":"13","author":"Guelsin GA","year":"2015","journal-title":"Blood Transfus"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18374"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13111"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15863"},{"key":"e_1_2_11_32_1","doi-asserted-by":"crossref","unstructured":"ThomasTA QiuA KimCY GordyDE MillerA TredicineM et\u00a0al.Reticulocytes in donor RBC units enhance RBC alloimmunization.2023.bioRxiv[Preprint].https:\/\/doi.org\/10.1101\/2023.01.25.525560","DOI":"10.1101\/2023.01.25.525560"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2023.282815"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12011"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2017.12.002"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2023.150750"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13920"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70536","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70536","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:10:06Z","timestamp":1781525406000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/bjh.70536"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70536","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]},"assertion":[{"value":"2025-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}