{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:14:13Z","timestamp":1783455253357,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370208"],"award-info":[{"award-number":["82370208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470200"],"award-info":[{"award-number":["82470200"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Multiple myeloma (MM) is a highly heterogeneous plasma cell malignancy whose progression and relapse are influenced by clonal heterogeneity. Although serum free light chains (sFLCs) are key biomarkers for tumour burden assessment, the clinical value of \u03bb,\n                    <jats:italic>\u03ba<\/jats:italic>\n                    and their ratio remains controversial. This study investigated the associations of sFLC\n                    <jats:italic>\u03ba<\/jats:italic>\n                    , \u03bb and the\n                    <jats:italic>\u03ba<\/jats:italic>\n                    \/\u03bb ratio with clinical features, cytogenetic abnormalities, prognosis and response to the VRd regimen (bortezomib, lenalidomide, dexamethasone) in newly diagnosed MM (NDMM) patients, aiming to optimize risk stratification. A retrospective analysis of 113 NDMM patients was conducted. Baseline clinical data, cytogenetic markers (\n                    <jats:italic>RB1<\/jats:italic>\n                    \/D13S319\/IGH\/1q21\/\n                    <jats:italic>P53<\/jats:italic>\n                    \/1p32) and treatment responses were collected, with stratification by renal function. Tumour proliferation, apoptosis and angiogenesis were assessed by immunohistochemistry. Prognostic factors were evaluated using Kaplan\u2013Meier and Cox regression analyses. A modified revised International Staging System (R\u2010ISS) (MR\u2010ISS) model incorporating sFLC\n                    <jats:italic>\u03ba<\/jats:italic>\n                    was then developed and temporally externally validated. Abnormal sFLC\n                    <jats:italic>\u03ba<\/jats:italic>\n                    indicated poor prognosis. Among NDMM patients with normal renal function, abnormal sFLC\n                    <jats:italic>\u03ba<\/jats:italic>\n                    was significantly associated with adverse clinical features, high tumour burden, an anti\u2010apoptotic and angiogenic tumour microenvironment, D13S319 deletion and a lower rate of deep remission after VRd induction. Moreover, the MR\u2010ISS model demonstrated superior risk discrimination compared with the R\u2010ISS. In conclusion, abnormal sFLC\n                    <jats:italic>\u03ba<\/jats:italic>\n                    is a potential marker of poor prognosis and suboptimal response to VRd therapy in NDMM. Integrating sFLC\n                    <jats:italic>\u03ba<\/jats:italic>\n                    with the R\u2010ISS improves risk stratification, providing new evidence for clinical application of this biomarker.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70541","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T07:30:08Z","timestamp":1778484608000},"page":"136-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preliminary investigation into the association of serum free kappa light chains with risk stratification, clonal evolution and precision therapy in multiple myeloma"],"prefix":"10.1111","volume":"209","author":[{"given":"Chenbo","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Henan Key Laboratory of Tumor Pathology Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Henan Key Laboratory of Tumor Pathology Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Henan Key Laboratory of Tumor Pathology Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Henan Key Laboratory of Tumor Pathology Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Li","sequence":"additional","affiliation":[{"name":"Henan Institute of Medical and Pharmaceutical Sciences Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuisheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Henan Key Laboratory of Tumor Pathology Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Henan Key Laboratory of Tumor Pathology Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27327"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-12-542662"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-019-0267-8"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2636"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.154070"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25117"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.242"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01162-7"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2267"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.48.7934"},{"key":"e_1_2_14_13_1","article-title":"International myeloma society\/international myeloma working group consensus recommendations on the definition of high\u2010risk multiple myeloma","volume":"43","author":"Avet\u2010Loiseau H","year":"2025","journal-title":"J Clin Oncol"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1124994"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13194856"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-024-01090-1"},{"issue":"7","key":"e_1_2_14_17_1","first-page":"1657","article-title":"Serum free light\u2010chain ratio at diagnosis is associated with early renal damage in multiple myeloma: a case series real\u2010world study","volume":"10","author":"De Novellis D","year":"2022","journal-title":"Biomedicine"},{"issue":"5","key":"e_1_2_14_18_1","first-page":"377","article-title":"The roles of serum free light chain ratio in the diagnosis and prognosis of newly diagnosed multiple myeloma","volume":"37","author":"Wang PF","year":"2016","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-018-0962-x"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26747"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-138602"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.118"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.126797"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.128"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2013.33.4.248"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-025-01286-w"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-198408"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06561.x"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.704033"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLML.2010.n.010"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-020-04162-8"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2025.09.013"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2025015901"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02614"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.8545"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70541","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:16:01Z","timestamp":1783451761000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/bjh.70541"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70541","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]},"assertion":[{"value":"2025-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}