{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:13:31Z","timestamp":1783455211531,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008335","name":"Arizona Biomedical Research Commission","doi-asserted-by":"publisher","award":["RFGA2022\u2010010\u201028"],"award-info":[{"award-number":["RFGA2022\u2010010\u201028"]}],"id":[{"id":"10.13039\/100008335","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Clinical decision support (CDS) can potentially improve the rate of heparin\u2010induced thrombocytopenia (HIT) diagnostic testing for patients who are at increased risk. We implemented and evaluated CDS utilizing the HIT computerized risk (HIT\u2010CR) score in a large healthcare system. The CDS was triggered by a HIT\u2010CR score of 4 and provided clinicians with a temporal graph of platelet counts and prompts to help further assess the risk of HIT. The primary outcome of this study was the percentage of patients at intermediate to high risk for HIT (4Ts scores \u22654) who underwent recommended diagnostic testing for HIT. Among those with 4Ts scores \u22654, the diagnostic testing rate increased from 28\/237 (11.8%) to 98\/288 (34.0%) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) after implementation of the CDS advisory. The rate of patients determined to have HIT was 6\/332 (1.8%) pre\u2010intervention and 13\/412 (3.2%) post\u2010intervention (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.25). Fourteen of the 26 patients with 4Ts scores \u22656 did not undergo diagnostic testing for HIT despite the CDS advisory, and eight had possible complications from undiagnosed HIT. A CDS tool using the HIT\u2010CR score for assessment of risk of HIT can increase the rate of diagnostic testing in patients with elevated risk of HIT, but there is potential for further improvement.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70551","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T04:30:15Z","timestamp":1778473815000},"page":"222-227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical decision support to aid in diagnosis of heparin\u2010induced thrombocytopenia"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0378-3958","authenticated-orcid":false,"given":"Tyler","family":"Gallo","sequence":"first","affiliation":[{"name":"Division of Clinical Data Analytics and Decision Support University of Arizona College of Medicine \u2013 Phoenix  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. William","family":"Heise","sequence":"additional","affiliation":[{"name":"Division of Clinical Data Analytics and Decision Support University of Arizona College of Medicine \u2013 Phoenix  Phoenix Arizona USA"},{"name":"Department of Medical Toxicology Banner \u2013 University Medical Center Phoenix  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Curry","sequence":"additional","affiliation":[{"name":"Division of Clinical Data Analytics and Decision Support University of Arizona College of Medicine \u2013 Phoenix  Phoenix Arizona USA"},{"name":"Department of Medical Toxicology Banner \u2013 University Medical Center Phoenix  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corneliu C.","family":"Antonescu","sequence":"additional","affiliation":[{"name":"Banner Health  Greeley Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Raschke","sequence":"additional","affiliation":[{"name":"Division of Clinical Data Analytics and Decision Support University of Arizona College of Medicine \u2013 Phoenix  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"issue":"6","key":"e_1_2_12_2_1","first-page":"1644","article-title":"The incidence of recognized heparin\u2010induced thrombocytopenia in a large","volume":"131","author":"Smythe MA","year":"2007","journal-title":"Tertiary Care Teach Hosp"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2017.05.024"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1602664"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018024489"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-008-0279-x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl-2011-000138"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2024.109171"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14359"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17086"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18902"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(96)00258-6"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199709)56:1<12::AID-AJH3>3.0.CO;2-5"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(18)30046-2"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.15.1849"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-04-778993"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2020.103453"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2196\/69333"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2023-002432"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl-2011-000089"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70551","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70551","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:15:27Z","timestamp":1783451727000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,10]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/bjh.70551"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70551","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,10]]},"assertion":[{"value":"2026-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}