{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:13:36Z","timestamp":1783455216222,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    S\u00e9zary syndrome (SS) is an aggressive cutaneous T\u2010cell lymphoma, characterized by erythroderma, lymphadenopathy and circulating malignant CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells. Despite therapeutic advances, SS remains an incurable disease. Early diagnosis is therefore essential for timely therapeutic intervention; however, reliable biomarkers to identify circulating SS cells are still lacking. Recent studies highlighted dysregulation of the ectoenzymes CD39, CD73 and CD38 in SS, suggesting a potential role for these molecules in the disease. Thirty\u2010three patients were enrolled in this study, and CD39\/CD73\/CD38 expression was analysed on circulating CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells by multiparametric flow cytometry, enabling discrimination between malignant and non\u2010malignant T\u2010cell subsets. SS cells exhibited marked CD39 or CD73 overexpression together with consistent CD38 downregulation, a pattern also confirmed in paired skin biopsy, whereas non\u2010malignant CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells largely maintained expression profiles comparable to healthy controls. Genotyping further identified\n                    <jats:italic>ENTPD1<\/jats:italic>\n                    single nucleotide polymorphism rs10748643 as a contributor to CD39 dysregulation, defining a CD39\u2010permissive subgroup characterized by CD39\n                    <jats:sup>+<\/jats:sup>\n                    SS cells. In conclusion, the combined overexpression of CD39 or CD73 and loss of CD38 defines a distinct tumour\u2010restricted immunophenotypic signature in SS. Integrating these ectoenzymes into flow cytometry panels may improve detection of malignant CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells across blood and skin, eventually strengthening diagnostic accuracy.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70562","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T08:46:39Z","timestamp":1779698799000},"page":"42-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utility of combined\n                    <scp>CD39<\/scp>\n                    \/\n                    <scp>CD73<\/scp>\n                    \/\n                    <scp>CD38<\/scp>\n                    expression for the detection of malignant T cells in S\u00e9zary syndrome"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7005-837X","authenticated-orcid":false,"given":"Sara","family":"Marchisio","sequence":"first","affiliation":[{"name":"Laboratory of Immunogenetics, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9598-3462","authenticated-orcid":false,"given":"Yuliya","family":"Yakymiv","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6870-0251","authenticated-orcid":false,"given":"Liyun","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory of Immunogenetics, Department of Medical Sciences University of Turin  Turin 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