{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:13:59Z","timestamp":1783455239171,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare condition associated with severe fetal thrombocytopenia and intracerebral haemorrhage. Antenatal management of subsequent pregnancies relies on intravenous immunoglobulin (IVIg); yet, practice varies internationally and UK data are limited. We conducted a national survey to characterise the current antenatal management of FNAIT across UK regional fetal medicine centres using an electronic, scenario\u2010based design. Responses were analysed descriptively, with \u226575% concordance considered strong agreement. Sixteen of 22 regional fetal medicine centres (73%) responded; all respondents were fetal medicine specialists or haematologists. There was strong consensus to treat standard\u2010 and high\u2010risk pregnancies associated with anti\u2010human platelet antigen (HPA)1a or anti\u2010HPA5b antibodies using weekly IVIg, most commonly at a dose of 1\u2009g\/kg\/week. Earlier initiation of IVIg was favoured for high\u2010risk pregnancies, while timing was more variable for standard\u2010risk cases. Corticosteroids were not routinely used in standard\u2010risk pregnancies but were considered in high\u2010risk scenarios. Fetal blood sampling and intrauterine platelet transfusion were generally avoided. Considerable variation was observed in delivery planning and in the management of pregnancies at risk without a prior confirmed diagnosis. This survey demonstrates the areas of both consistency and variation in UK practice, highlighting gaps in the evidence base and priorities for future research and guidelines development.<\/jats:p>","DOI":"10.1111\/bjh.70564","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T01:51:22Z","timestamp":1779241882000},"page":"240-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fetal and neonatal alloimmune thrombocytopenia (\n                    <scp>FNAIT<\/scp>\n                    ): Survey of\n                    <scp>UK<\/scp>\n                    fetal medicine centres on antenatal management of subsequent affected pregnancies"],"prefix":"10.1111","volume":"209","author":[{"given":"Asha","family":"Aggarwal","sequence":"first","affiliation":[{"name":"Department of Clinical Haematology Churchill Hospital  Oxford UK"},{"name":"NHS Blood and Transplant John Radcliffe Hospital  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7298-5716","authenticated-orcid":false,"given":"Catherine","family":"Prodger","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Churchill Hospital  Oxford UK"},{"name":"NHS Blood and Transplant John Radcliffe Hospital  UK"},{"name":"Radcliffe Department of Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4112-4299","authenticated-orcid":false,"given":"Brian","family":"Hockley","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant Sheffield Blood Centre  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Will","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Haematology Addenbrooke's Hospital  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2375-7503","authenticated-orcid":false,"given":"Mike F.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Churchill Hospital  Oxford UK"},{"name":"NHS Blood and Transplant John Radcliffe Hospital  UK"},{"name":"Radcliffe Department of Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lani","family":"Lieberman","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2884-9247","authenticated-orcid":false,"given":"James B.","family":"Bussel","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Vlachodimitropoulou","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine King's College Hospital  London UK"},{"name":"Ontario Fetal Center Mount Sinai Hospital, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-5616","authenticated-orcid":false,"given":"Michael J. R.","family":"Desborough","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Churchill Hospital  Oxford UK"},{"name":"NHS Blood and Transplant John Radcliffe Hospital  UK"},{"name":"Radcliffe Department of Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17731"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.04026.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18173"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.7.2280"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31823403f4"},{"key":"e_1_2_11_7_1","unstructured":"LinesC PittamG.Screening for fetomaternal alloimmune thrombocytopenia External review against programme appraisal criteria for the UK National Screening Committee (UK NSC). 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