{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:52:19Z","timestamp":1790614339212,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    This study aimed to assess whether routine nephrology examinations could predict renal amyloidosis in kidney disease patients with monoclonal gammopathy. A total of 356 consecutive hospitalized patients in the nephrology department with monoclonal gammopathy performed renal biopsies, including 50 renal amyloidosis patients and 306 non\u2010renal amyloidosis patients, were included after strict filtering. Laboratory and imaging data were collected for each patient. Renal amyloidosis patients exhibited significantly higher 24\u2010h proteinuria and estimated glomerular filtration rate and decreased serum creatinine (SCr), albumin and immunoglobin M, with lower\n                    <jats:italic>\u03ba<\/jats:italic>\n                    light chain and\n                    <jats:italic>\u03ba<\/jats:italic>\n                    \/\n                    <jats:italic>\u03bb<\/jats:italic>\n                    ratio in urine and serum. Higher 24\u2010h proteinuria and 24\u2010h microalbuminuria and lower random urine\n                    <jats:italic>\u03ba<\/jats:italic>\n                    \/\n                    <jats:italic>\u03bb<\/jats:italic>\n                    ratio, serum\n                    <jats:italic>\u03ba<\/jats:italic>\n                    light chain, serum\n                    <jats:italic>\u03ba<\/jats:italic>\n                    \/\n                    <jats:italic>\u03bb<\/jats:italic>\n                    ratio and SCr were significant risk factors for renal amyloidosis. Nomogram model identified albumin, 24\u2010h urinary microalbumin excretion rate, 24\u2010h urine\n                    <jats:italic>\u03ba<\/jats:italic>\n                    light chain, 24\u2010h urine\n                    <jats:italic>\u03ba<\/jats:italic>\n                    \/\n                    <jats:italic>\u03bb<\/jats:italic>\n                    ratio and serum IgM as combined predictors of renal amyloidosis (area under the curve 0.781, 95% CI 0.718\u20130.854). Combined biomarkers (albumin, 24\u2010h urinary microalbumin excretion rate, 24\u2009h urine\n                    <jats:italic>\u03ba<\/jats:italic>\n                    light chain, 24\u2010h urine\n                    <jats:italic>\u03ba<\/jats:italic>\n                    \/\n                    <jats:italic>\u03bb<\/jats:italic>\n                    ratio and serum IgM) effectively predicted renal amyloidosis in kidney disease patients with monoclonal gammopathy.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70565","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T01:19:26Z","timestamp":1779153566000},"page":"580-588","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Renal amyloidosis prediction in kidney disease patients accompanied by monoclonal gammopathy"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9225-9866","authenticated-orcid":false,"given":"Siyu","family":"Bao","sequence":"first","affiliation":[{"name":"Department of Nephrology Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Key Laboratory of Kidney and Blood Purification  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Xun","sequence":"additional","affiliation":[{"name":"Department of Nephrology Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Key Laboratory of Kidney and Blood Purification  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3146-638X","authenticated-orcid":false,"given":"Wensi","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Nephrology Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Key Laboratory of Kidney and Blood Purification  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daxi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Key Laboratory of Kidney and Blood Purification  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Key Laboratory of Kidney and Blood Purification  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Key Laboratory of Kidney and Blood Purification  Shanghai China"},{"name":"Shanghai Medical Center of Kidney  Shanghai China"},{"name":"Shanghai Institute of Kidney and Dialysis  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Nephrology Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Key Laboratory of Kidney and Blood Purification  Shanghai China"},{"name":"Shanghai Medical Center of Kidney  Shanghai China"},{"name":"Shanghai Institute of Kidney and Dialysis  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Zhongshan Hospital, Fudan University  Shanghai China"},{"name":"Key Laboratory of Kidney and Blood Purification  Shanghai China"},{"name":"Shanghai Medical Center of Kidney  Shanghai China"},{"name":"Shanghai Institute of Kidney and Dialysis  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Hematology Zhongshan Hospital (Xiamen Branch), Fudan University  Xiamen Fujian China"},{"name":"Department of Hematology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Clinical Research Center for Precision Medicine of Abdominal Tumor of Fujian Province  Xiamen Fujian China"},{"name":"Xiamen Key Laboratory of Biotherapy  Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2024.8124"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26796"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.126664"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0077-4"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.408"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-445304"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.046870"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2023.02.004"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-017-0426-6"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000522370"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs501"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03215.x"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012662"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.04.013"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm041"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.14740\/jh866"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25819"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.117143"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-020-00391-2"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2025.2453088"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506696"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01204.x"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.5724"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8859340"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbr.2016.12.002"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2022.01.003"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLML.2011.n.011"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-194241"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-019-02811-x"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.0898"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.02183.x"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.12.2637.2637"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506120902879269"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.03.036"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20829"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001884"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70565","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70565","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T03:11:26Z","timestamp":1786504286000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/bjh.70565"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70565","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]},"assertion":[{"value":"2026-01-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}