{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T03:30:25Z","timestamp":1786505425803,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    In B\u2010cell acute lymphoblastic leukaemia (B\u2010ALL), paired box\u00a05 (\n                    <jats:italic>PAX5)<\/jats:italic>\n                    rearrangement (\n                    <jats:italic>PAX5\u2010r<\/jats:italic>\n                    ) represents a critical genetic driver. Here, we report the identification of an in\u2010frame\n                    <jats:italic>PAX5::GSE1<\/jats:italic>\n                    fusion gene in a patient with B\u2010ALL. Functional characterization revealed that the PAX5::GSE1 protein localizes to the nucleus, promotes cell proliferation and suppresses wild\u2010type PAX5 transcriptional activity. Notably, its transcript levels correlated with treatment response, supporting its utility as a minimal residual disease biomarker. By analysing 330 patients with\n                    <jats:italic>PAX5\u2010r<\/jats:italic>\n                    B\u2010ALL, we identified 76 distinct in\u2010frame partner genes and delineated their breakpoint characteristics. Integrated multi\u2010cohort transcriptomic analysis further revealed that\n                    <jats:italic>PAX5\u2010r<\/jats:italic>\n                    induces a convergent expression profile relative to healthy individuals, characterized by dysregulation of the retinoblastoma transcriptional corepressor 1 (RB1) and p53 pathways and overexpression of nucleophosmin 1 (\n                    <jats:italic>NPM1)<\/jats:italic>\n                    . These findings help to clarify core molecular mechanisms underlying\n                    <jats:italic>PAX5\u2010r<\/jats:italic>\n                    \u2010driven leukaemogenesis and highlight potential therapeutic vulnerabilities.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70578","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T03:32:21Z","timestamp":1779939141000},"page":"480-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of\n                    <scp>\n                      <i>GSE1<\/i>\n                    <\/scp>\n                    as a\n                    <scp>\n                      <i>PAX5<\/i>\n                    <\/scp>\n                    fusion partner and characterization of\n                    <scp>\n                      <i>PAX5<\/i>\n                    <\/scp>\n                    fusion signature in B\u2010cell acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"209","author":[{"given":"Haina","family":"Wang","sequence":"first","affiliation":[{"name":"Liaoning Key Laboratory of Hematopoietic Stem Cell Transplantation and Translational Medicine, Department of Hematology The Second Hospital of Dalian Medical University  Dalian China"},{"name":"Liaoning Medical Center for Hematopoietic Stem Cell Transplantation The Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Xue","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Hematopoietic Stem Cell Transplantation and Translational Medicine, Department of Hematology The Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Yan","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Hematopoietic Stem Cell Transplantation and Translational Medicine, Department of Hematology The Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Liaoning Medical Center for Hematopoietic Stem Cell Transplantation The Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zong","sequence":"additional","affiliation":[{"name":"Liaoning Medical Center for Hematopoietic Stem Cell Transplantation The Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Diamond Bay Institute of Hematology Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Huang","sequence":"additional","affiliation":[{"name":"Liaoning Medical Center for Hematopoietic Stem Cell Transplantation The Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchen","family":"Liu","sequence":"additional","affiliation":[{"name":"Diamond Bay Institute of Hematology Second Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of Genome and Personalized Medicine, Institute of Cancer Stem Cell Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4109-2602","authenticated-orcid":false,"given":"Jinsong","family":"Yan","sequence":"additional","affiliation":[{"name":"Liaoning Key Laboratory of Hematopoietic Stem Cell Transplantation and Translational Medicine, Department of Hematology The Second Hospital of Dalian Medical University  Dalian China"},{"name":"Liaoning Medical Center for Hematopoietic Stem Cell Transplantation The Second Hospital of Dalian Medical University  Dalian China"},{"name":"Diamond Bay Institute of Hematology Second Hospital of Dalian Medical University  Dalian 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