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Thrombocytosis is common in SCD, especially in response to acute chest syndrome, vaso\u2010occlusive crises and chronic haemolysis. Increased platelet activity contributes to the proinflammatory and prothrombotic environment. Activated platelets release platelet\u2010derived microparticles (PMPs) containing phospholipids and inflammatory mediators, which enhance thrombin generation, entrap leucocytes and promote cellular adhesions leading to endothelial dysfunction and vaso\u2010occlusion within the microvasculature. This review provides insights into the mechanisms underlying thrombocytosis and PMP formation in SCD and discusses therapeutic strategies targeting platelet activation to mitigate inflammation and vascular complications.<\/jats:p>","DOI":"10.1111\/bjh.70579","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T14:35:29Z","timestamp":1779978929000},"page":"420-431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Thrombocytosis and the generation of platelet\u2010derived microparticles in the pathophysiology of sickle cell disease"],"prefix":"10.1111","volume":"209","author":[{"given":"Giao N.","family":"L\u00ea","sequence":"first","affiliation":[{"name":"Department of Haematology Children's Health Ireland at Crumlin  Dublin Ireland"},{"name":"Department of Haematology, School of Medicine Trinity College Dublin  Dublin 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