{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T03:30:47Z","timestamp":1786505447475,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470186"],"award-info":[{"award-number":["82470186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100211"],"award-info":[{"award-number":["82100211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82500242"],"award-info":[{"award-number":["82500242"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20232039"],"award-info":[{"award-number":["BK20232039"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018904","name":"Beijing Xisike Clinical Oncology Research Foundation","doi-asserted-by":"publisher","award":["Y\u2010SYBLD2022RWR\u20100013"],"award-info":[{"award-number":["Y\u2010SYBLD2022RWR\u20100013"]}],"id":[{"id":"10.13039\/100018904","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Although antiviral prophylaxis is standard for lymphoma patients with chronic hepatitis B virus (HBV) infection to prevent HBV reactivation (HBVr), the optimal timing for high\u2010risk patients (baseline HBV deoxyribonucleic acid (DNA) \u22654\u2009log10 IU\/mL) during immunochemotherapy remains unclear. A multicentre retrospective study analysed 112 chronic HBV patients among 1120 newly diagnosed diffuse large B\u2010cell lymphoma (DLBCL) patients, stratified by baseline viral load (low: &lt;10\n                    <jats:sup>4<\/jats:sup>\n                    \u2009IU\/mL,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200982; high: \u226510\n                    <jats:sup>4<\/jats:sup>\n                    \u2009IU\/mL,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200930). We assessed antiviral timing, virological dynamics and clinical outcomes. Antivirals (mainly entecavir) suppressed HBV DNA to undetectable levels in high\u2010load patients (median start 1.65\u2009\u00d7\u200910\n                    <jats:sup>6<\/jats:sup>\n                    \u2009IU\/mL;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). The 3\u2010year cumulative HBVr rates were low (4.2% overall; 4.5% high vs. 4.1% low load,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.955), with one fatal HBVr after discontinuation. Liver toxicity was mild (grade 1\u20132 transaminase elevations: 33.3%\u201336.7%). High and low viral load groups achieved comparable 3\u2010year progression\u2010free survival (80.9% vs. 70.6%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.137), overall response rates (86.7% vs. 82.9%) and complete remission rates (70.0% vs. 64.6%). Propensity score\u2010matched analysis confirmed no significant differences in progression\u2010free survival or HBVr. Concurrent initiation of antiviral prophylaxis with immunochemotherapy is safe and effective, preventing HBVr and enabling timely immunochemotherapy in DLBCL patients with high HBV DNA levels.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70584","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:26:44Z","timestamp":1780385204000},"page":"503-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Concurrent antiviral\u2013immunochemotherapy strategy safely overcomes high hepatitis B viral load barrier in diffuse large B\u2010cell lymphoma: A multicentre cohort study"],"prefix":"10.1111","volume":"209","author":[{"given":"Yuxiao","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Hematology Jiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Geriatrics The Second Hospital of Nanjing, Nanjing University of Chinese Medicine  Nanjing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiran","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine Nanjing Medical University  Nanjing Jiangsu 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Personalized Cancer Medicine Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9931-4055","authenticated-orcid":false,"given":"Jianyong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University  Nanjing Jiangsu China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation 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