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We analysed the characteristics, toxicities, response and survival of patients with PCL\/CNS\u2010multiple myeloma (MM) treated with cesnicabtagene autoleucel (ARI0002h) at three Spanish centres (2020\u20132025). PCL was defined as per International Myeloma Working Group (IMWG) 2021 criteria; CNS\u2010MM by leptomeningeal and\/or intraparenchymal involvement. Nineteen patients (68% female; median age 61) were included: 12 patients had PCL, 5 had CNS\u2010MM, and 2 had dual involvement. Fifty per cent had primary PCL. In CNS\u2010MM, all had leptomeningeal disease and one had also intraparenchymal lesions. Fifty\u2010seven per cent received CNS\u2010directed therapy. Seventy four per cent harboured high\u2010risk cytogenetics. Median prior lines: 3; 74% had haematopoietic stem cell transplantation (HSCT); two had prior B\u2010cell maturation antigen (BCMA) exposure. One patient died pre\u2010apheresis and one during manufacturing; 17 (89%) received ARI0002h. Cytokine release syndrome (CRS) occurred in 76% (none \u2265G3), G3 immune effector cell (IEC)\u2010associated neurotoxicity syndrome (ICANS) occurred in one case (not CNS\u2010MM) and IEC\u2010associated haemophagocytic lymphohistiocytosis\u2010like syndrome (IEC\u2010HS) occurred in 18% (one fatal). Overall response rate (ORR) was 88% at day +100, of which 87% achieved \u2265 very good partial response (VGPR) and 80% complete CNS response. Median progression\u2010free survival (PFS) and overall survival (OS) were 10.5 and 15.9\u2009months respectively. ARI0002h induces deep responses in relapsed uHRMM, supporting inclusion of PCL and CNS\u2010MM in clinical trials.<\/jats:p>","DOI":"10.1111\/bjh.70586","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:41:21Z","timestamp":1780562481000},"page":"610-620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cesni\u2010cel (\n                    <scp>ARI0002h<\/scp>\n                    ) in ultra\u2010high\u2010risk multiple myeloma with plasma cell leukaemia or central nervous system involvement"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6293-2716","authenticated-orcid":false,"given":"Carlos","family":"Jimenez\u2010Mira","sequence":"first","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona  Barcelona 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Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azucena","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Miguel","family":"Mateos","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Espa\u00f1ol\u2010Rego","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona  Barcelona 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