{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T03:30:41Z","timestamp":1786505441087,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2508900"],"award-info":[{"award-number":["2023YFC2508900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370162"],"award-info":[{"award-number":["82370162"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170217"],"award-info":[{"award-number":["82170217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2024C03162"],"award-info":[{"award-number":["2024C03162"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"Summary<\/jats:title>\n \n Acute myeloid leukaemia (AML) patients with concurrent FMS\u2010like tyrosine kinase 3 internal tandem duplication (\n FLT3\u2010<\/jats:italic>\n ITD<\/jats:italic>\n ), nucleophosmin 1 (\n NPM1<\/jats:italic>\n ) and DNA methyltransferase 3 alpha (\n DNMT3A<\/jats:italic>\n ) mutations exhibit heterogeneous treatment outcomes. To identify optimal strategies for this subset, we retrospectively analysed 2541 AML patients with next\u2010generation sequencing from 2016 to 2023. Among them, 113 harboured triple mutations and had treatment outcomes: 79 received allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT), and 34 underwent continuous chemotherapy (CMT). Compared with CMT, allo\u2010HSCT was associated with superior 2\u2010year overall survival (OS) (62.2% vs. 17.8%,\n p<\/jats:italic>\n \u2009<\u20090.001). However, no clear additional benefit from allo\u2010HSCT was observed in patients who achieved composite complete remission (CRc) with\n DNMT3A<\/jats:italic>\n measurable residual disease (MRD) negativity or complete remission with negative multiparameter flow cytometry MRD after the first cycle of CMT (CMT\n 1st<\/jats:sup>\n ). Among patients who underwent allo\u2010HSCT, those in CRc after CMT\n 1st<\/jats:sup>\n had significantly improved post\u2010transplant 2\u2010year OS (71.9% vs. 44.1%,\n p<\/jats:italic>\n \u2009=\u20090.028), leukaemia\u2010free survival (65.4% vs. 40.2%,\n p<\/jats:italic>\n \u2009=\u20090.029) and non\u2010relapse mortality (17.4% vs. 40.4%,\n p<\/jats:italic>\n \u2009=\u20090.037). CRc rates were higher with venetoclax\u2010based intensive (88.2%) or non\u2010intensive (63.6%) CMT than with CMT alone (\n p<\/jats:italic>\n \u2009=\u20090.001). In conclusion, this study offers a potential treatment paradigm for AML patients with co\u2010occurring\n FLT3\u2010<\/jats:italic>\n ITD,\n NPM1<\/jats:italic>\n and\n DNMT3A<\/jats:italic>\n mutations.\n <\/jats:p>","DOI":"10.1111\/bjh.70593","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T03:20:41Z","timestamp":1780456841000},"page":"642-652","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimizing treatment selection and timing of allogeneic haematopoietic stem cell transplantation in acute myeloid leukaemia with concurrent feline McDonough sarcoma (FMS)\u2010like tyrosine kinase 3 internal tandem duplication, nucleophosmin 1 and deoxyribonucleic acid (DNA) methyltransferase 3 alpha mutations"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7592-6905","authenticated-orcid":false,"given":"Ruixin","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"},{"name":"Hematopoietic Stem Cell Transplantation Center, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7267-259X","authenticated-orcid":false,"given":"Yiyi","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Malignancies Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglin","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"},{"name":"Hematopoietic Stem Cell Transplantation Center, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Malignancies Hangzhou China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinjun","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Malignancies Hangzhou China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"},{"name":"Hematopoietic Stem Cell Transplantation Center, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"},{"name":"Zhejiang Key Laboratory for Precision Diagnosis and Treatment of Hematological Malignancies Hangzhou China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders Hangzhou 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Science Tianjin China"},{"name":"Hematopoietic Stem Cell Transplantation Center, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizhou","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China"},{"name":"Tianjin Institutes of Health Science Tianjin China"},{"name":"Hematopoietic Stem Cell Transplantation Center, Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin 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