{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:12:15Z","timestamp":1789193535812,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2026JJ81611"],"award-info":[{"award-number":["2026JJ81611"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    To identify key cytokines for the differentiation and treatment monitoring of haemophagocytic lymphohistiocytosis (\n                    <jats:styled-content style=\"fixed-case\">HLH<\/jats:styled-content>\n                    ). We retrospectively analysed the clinical data and cytokine profiles from 66 patients with\n                    <jats:styled-content style=\"fixed-case\">HLH<\/jats:styled-content>\n                    , sepsis, Kawasaki disease (\n                    <jats:styled-content style=\"fixed-case\">KD<\/jats:styled-content>\n                    ) and infectious mononucleosis (\n                    <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>\n                    ). Hierarchical clustering analysis was performed among those diseases. The diagnostic value of the markers was assessed using logistic regression and receiver operating characteristic (\n                    <jats:styled-content style=\"fixed-case\">ROC)<\/jats:styled-content>\n                    curves. Longitudinal changes in cytokines were detected in\n                    <jats:styled-content style=\"fixed-case\">HLH<\/jats:styled-content>\n                    patients. Cluster analysis revealed substantial overlap in the cytokine profiles between HLH and IM, characterized by high levels of C\u2010X\u2010C motif chemokine ligand 9\n                    <jats:styled-content style=\"fixed-case\">(<\/jats:styled-content>\n                    CXCL9), C\u2010X\u2010C motif chemokine ligand\n                    <jats:styled-content style=\"fixed-case\">10 (<\/jats:styled-content>\n                    CXCL10), interferon\u2010gamma (IFN\u2010\u03b3), soluble\u00a0cluster of differentiation 25 (sCD25) and interleukin\u201018 (IL\u201018). The cytokine profiles differed from sepsis and KD patients. The combined detection of CXCL9 and haemoglobin (Hb) achieved an area under the curve (AUC) of 0.943 for distinguishing Epstein\u2013Barr virus\u2010related HLH (EBV\u2010HLH) from IM. CXCL9 was significantly correlated with aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) in HLH patients. Moreover, high levels of CXCL9 were associated with more severe clinical manifestations. During the monitoring of HLH cases, trends in CXCL9 and LDH levels correlated with disease progression.In conclusion, differences in cytokine profiles contribute to disease differentiation, and detection of CXCL9 holds promise for HLH diagnosis and longitudinal monitoring.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70610","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T02:17:36Z","timestamp":1781317056000},"page":"1166-1174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The value of C\u2010X\u2010C motif chemokine ligand 9 (\n                    <scp>CXCL9<\/scp>\n                    ) in the differential diagnosis and management of haemophagocytic lymphohistiocytosis"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5400-1242","authenticated-orcid":false,"given":"Can","family":"Liu","sequence":"first","affiliation":[{"name":"Clinical Laboratory, The Affiliated Children's Hospital of Xiangya School of Medicine Central South University (Hunan Children's Hospital)  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Luo","sequence":"additional","affiliation":[{"name":"Lymphoma Oncology Department, The Affiliated Children's Hospital of Xiangya School of Medicine Central South University (Hunan Children's Hospital)  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Yang","sequence":"additional","affiliation":[{"name":"Lymphoma Oncology Department, The Affiliated Children's Hospital of Xiangya School of Medicine Central South University (Hunan Children's Hospital)  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caizhi","family":"Huang","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, The Affiliated Children's Hospital of Xiangya School of Medicine Central South University (Hunan Children's Hospital)  Changsha 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