{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:13:16Z","timestamp":1789193596884,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2507802"],"award-info":[{"award-number":["2023YFC2507802"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470136"],"award-info":[{"award-number":["82470136"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470138"],"award-info":[{"award-number":["82470138"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010041","name":"Tianjin Municipal Science and Technology Committee","doi-asserted-by":"publisher","award":["25ZXZSSS00510"],"award-info":[{"award-number":["25ZXZSSS00510"]}],"id":[{"id":"10.13039\/501100010041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Emicizumab is an established prophylactic therapy for haemophilia A (HA). However, real\u2010world multicentre evidence on long\u2010term outcomes, particularly in a resource\u2010constrained setting, remains limited. We aimed to evaluate real\u2010world outcomes in patients with HA receiving emicizumab prophylaxis across multiple centres with extended follow\u2010up. We conducted a multicentre retrospective study of patients with HA who received emicizumab prophylaxis for \u22651\u2009year across 25 centres. Outcomes included annualized bleeding rate (ABR), annualized joint bleeding rate (AJBR), bleeding events, target joint status and adverse events. A total of 132 patients (131 males and 1 female) were included, with a median age at switch of 2.0\u2009years (interquartile range [IQR], 1.0\u20134.8). Over a median follow\u2010up of 26\u2009months (IQR: 16.0\u201340.0), the negative binomial regression model\u2010based ABR for all bleeds was 0.81 (95% confidence interval [CI], 0.62\u20131.07). Across 12\u2010month intervals, both calculated mean and negative binomial regression model\u2010based AJBR remained between 0.1 and 0.3. Of the 74 baseline target joints, 95.9% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200971) resolved and no new target joints developed. Forty\u2010two patients (31.8%) received factor concentrates during emicizumab treatment. Injection\u2010site reactions occurred in 7.6% of patients, with no thromboembolic or fatal events observed. Long\u2010term emicizumab prophylaxis provides sustained bleeding control, joint protection and a favourable safety profile.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70623","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:14:37Z","timestamp":1781579677000},"page":"1269-1279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term outcomes with emicizumab prophylaxis for haemophilia A in China: A multicentre, large\u2010cohort retrospective study"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5333-7739","authenticated-orcid":false,"given":"Yuan","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Tianjin Key Laboratory of Gene Therapy for Blood Diseases, CAMS Key Laboratory of Gene Therapy for Blood Diseases, Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin China"},{"name":"Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen Children's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Second Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7981-2786","authenticated-orcid":false,"given":"Liya","family":"He","sequence":"additional","affiliation":[{"name":"Guangzhou Women and Children's Medical Center, Guangzhou Medical University  Guangzhou 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Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Haematology Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Affiliated Hospital of Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3668-3558","authenticated-orcid":false,"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Hospital of Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7698-7695","authenticated-orcid":false,"given":"Zeping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Gai","sequence":"additional","affiliation":[{"name":"Department of Hematology Huaibei People's Hospital, Anhui Province  Huaibei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Fourth Hospital of Harbin Medical University  Harbin Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Sun","sequence":"additional","affiliation":[{"name":"Qilu Hospital of Shandong University Dezhou Hospital  Dezhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Li","sequence":"additional","affiliation":[{"name":"Chengdu New Century Women's and Children's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Hematology Children's Hospital of Shanxi  Taiyuan 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