{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T03:31:00Z","timestamp":1786505460532,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016016","name":"Gilead UK and Ireland Corporate Contributions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The optimal strategy to prevent and treat invasive fungal infections (IFIs) in children receiving allogeneic haematopoietic stem cell transplantation (HSCT) is not well established. A paediatric bone marrow transplant (BMT) working group set up UK national guidelines for the management of IFI and conducted a prospective study to assess the impact of these on incidence and outcomes. From March 2017 to December 2021, 358 children who received HSCT were prospectively included. Most children (82%) received either itraconazole (41%) or liposomal amphotericin B (41%) prophylaxis with a median duration of 170\u2009days (interquartile range [IQR] 101\u2013279). Cumulative incidence of possible\/probable\/proven IFI at 1 year was 17.6%, with no significant differences in children receiving itraconazole or liposomal amphotericin B (15.7% vs. 15.9%, 0.997). In multivariate analysis models (Fine\u2013Gray hazard ratio) underlying malignant disease and low azoles therapeutic drug monitoring levels were independently associated with development of IFI. Children with probable\/proven IFI had a higher 1\u2010year transplant\u2010related mortality (22% vs. 5.7%, Gray's test,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). By adopting standardized anti\u2010fungal prophylaxis, the incidence of proven\/probable IFI in a large cohort of transplanted children was 5% and these showed significant decreased survival, warranting tailored prophylactic strategies in high\u2010risk patients.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70628","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:53:14Z","timestamp":1782892394000},"page":"670-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of invasive fungal infections in 358 children undergoing allogeneic haematopoietic stem cell transplantation: A prospective UK study"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3777-0394","authenticated-orcid":false,"given":"Giorgio","family":"Ottaviano","sequence":"first","affiliation":[{"name":"Department of Blood and Marrow Transplantation Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"},{"name":"Pediatrics Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Lanino","sequence":"additional","affiliation":[{"name":"Pediatrics Fondazione IRCCS San Gerardo dei Tintori  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Nademi","sequence":"additional","affiliation":[{"name":"Department of Paediatric Hematopoietic Stem Cell Transplant Great North Children's Hospital, Royal Victoria Infirmary  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beki","family":"James","sequence":"additional","affiliation":[{"name":"Paediatric Haematology and Oncology Leeds Children's Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Powys","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplantation Royal Manchester Children's Hospital  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0480-3911","authenticated-orcid":false,"given":"Persis","family":"Amrolia","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplantation Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9449-8476","authenticated-orcid":false,"given":"Kanchan","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplantation Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplantation Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arina","family":"Lazareva","sequence":"additional","affiliation":[{"name":"Department of Blood and Marrow Transplantation Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lawson","sequence":"additional","affiliation":[{"name":"Department of Haematology Birmingham Children's Hospital  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine","family":"Patrick","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology Sheffield Children NHS Foundation Trust  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Furness","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology Royal Marsden Hospital  Sutton 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