{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T03:30:44Z","timestamp":1786505444859,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100236"],"award-info":[{"award-number":["82100236"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Lymphoma\u2010associated haemophagocytic lymphohistiocytosis (HLH) represents a rare and life\u2010threatening hyperinflammatory syndrome with a dismal prognosis, largely due to its poorly understood pathogenesis and unclear distinctions from non\u2010lymphoma associated HLH (NLAHS). To elucidate these differences, we performed an integrated multiomics analysis on peripheral blood samples from patients with newly diagnosed lymphoma\u2010associated HLH (LAHS), NLAHS and healthy controls (NC). Single\u2010cell ribonucleic acid sequencing (scRNA\u2010seq) analysis (4 LAHS, 3 NLAHS, 2 NC) revealed that LAHS is characterized by enhanced glycolytic activity in significantly expanded monocyte populations, notably within a distinct subset of pituitary tumor\u2010transforming gene 1\n                    <jats:sup>+<\/jats:sup>\n                    (\n                    <jats:italic>PTTG1<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    ) monocytes. Metabolomic profiling (21 LAHS, 11 NLAHS, 7 NC) further confirmed elevated levels of glycolytic products, such as lactate and pyruvate. Clinically, hyperlactataemia (&gt;5.1\u2009mmol\/L,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200984) emerged as a significant independent predictor of poor survival in LAHS, with a median overall survival of only 43.5\u2009days (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Remission induced by treatment was associated with a reversal of this hypermetabolic phenotype. Cell communication analysis revealed upregulated thrombospondin signalling from\n                    <jats:italic>PTTG1<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    monocytes, linked to glycolytic activity. Our findings indicate that LAHS is characterized by a pronounced Warburg\u2010like metabolic state, primarily involving glycolytic monocytes. Hyperlactataemia is associated with adverse outcomes and may guide the development of novel therapeutic strategies targeting immunometabolic pathways.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70637","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:07:29Z","timestamp":1782925649000},"page":"448-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyperlactataemia in lymphoma\u2010associated haemophagocytic lymphohistiocytosis: Linked to monocytic glycolysis and adverse prognosis"],"prefix":"10.1111","volume":"209","author":[{"given":"Xuelian","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou PR China"},{"name":"Zhejiang University Cancer Center  Hangzhou Zhejiang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangshun","family":"You","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou PR China"},{"name":"Zhejiang University Cancer Center  Hangzhou Zhejiang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou PR China"},{"name":"Zhejiang University Cancer Center  Hangzhou Zhejiang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou PR China"},{"name":"Zhejiang University Cancer Center  Hangzhou Zhejiang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou PR China"},{"name":"Zhejiang University Cancer Center  Hangzhou Zhejiang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy Zhejiang University  Hangzhou Zhejiang PR China"},{"name":"Zhejiang Provincial Clinical Research Center for Hematological Disorders  Hangzhou PR China"},{"name":"Zhejiang University Cancer Center  Hangzhou Zhejiang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Cosmos Wisdom Biotech Co. 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