{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:00:39Z","timestamp":1792166439415,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Neutropenia in general is defined as a blood neutrophil count of less than 1.5\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L, in severe neutropenia counts drop to less than 0.5\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L, but the definition of neutropenia varies according to the patient's ethnic origin and age. For Caucasian adults, the absolute neutrophil count (ANC) threshold of 1.8\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L is adopted for the definition of neutropenia according to the World Health Organization (see Fioredda et\u00a0al. (1)). It can be inherited or acquired, and it is an uncommon haematological finding in adult outpatient clinics. Neutropenia can result from decreased production of neutrophil precursors in the bone marrow, as in the case of severe congenital neutropenia, or from increased utilization of neutrophils in some bacterial infections, or accelerated destruction as is the case with drug\u2010induced neutropenia, viral infections and autoimmune neutropenia. Severe chronic neutropenia increases susceptibility to bacterial or fungal infections. Treating severe chronic neutropenia patients with granulocyte colony\u2010stimulating factor (G\u2010CSF) can increase neutrophil counts for most types of neutropenia. This article will provide guidance on diagnosing and managing severe chronic neutropenia in adult patients and provides a transition programme from adolescence to adulthood.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70640","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T08:13:49Z","timestamp":1782720829000},"page":"432-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnosis and management of neutropenia in adults: Expert guidance"],"prefix":"10.1111","volume":"209","author":[{"given":"Karl","family":"Welte","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Children's Hospital Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Zeidler","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hematology, Clinical Immunology, and Rheumatology University Hospital Tuebingen  Tuebingen Germany"},{"name":"Medical School Hannover  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Skokowa","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hematology, Clinical Immunology, and Rheumatology University Hospital Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7467-8058","authenticated-orcid":false,"given":"Sabine","family":"Mellor\u2010Heineke","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Children's Hospital Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey Anna","family":"Bolyard","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Dale","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000872"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25756"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.110288"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014818"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-482612"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-03-634493"},{"key":"e_1_2_13_8_1","article-title":"Congenital and acquired chronic neutropenias: challenges, perspectives and implementation of the EuNet\u2010INNOCHRON action","volume":"4","author":"Papadaki HA","year":"2020","journal-title":"Hema"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2016.1.38"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2019.06.003"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.32"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14887"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2009.01.007"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022017739"},{"key":"e_1_2_13_15_1","first-page":"429","article-title":"Myelodysplasia syndrome and acute myeloid leukemia in patients with congenital neutropenia receiving G\u2010CSF therapy","volume":"96","author":"Freedman MH","year":"2000","journal-title":"Blood"},{"key":"e_1_2_13_16_1","first-page":"45","article-title":"Analysis of risk factors for myelodysplasias, leukemias and death from infection among patients with congenital neutropenia. 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