{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:11:49Z","timestamp":1789193509745,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["SHJDBF2024210"],"award-info":[{"award-number":["SHJDBF2024210"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["GSPJS202414"],"award-info":[{"award-number":["GSPJS202414"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["LCZX202512"],"award-info":[{"award-number":["LCZX202512"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["GSPJS202420"],"award-info":[{"award-number":["GSPJS202420"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002949","name":"Government of Jiangsu Province","doi-asserted-by":"publisher","award":["GSPJS202417"],"award-info":[{"award-number":["GSPJS202417"]}],"id":[{"id":"10.13039\/501100002949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010854","name":"Jiangsu Provincial Commission of Health and Family Planning","doi-asserted-by":"publisher","award":["M2024059"],"award-info":[{"award-number":["M2024059"]}],"id":[{"id":"10.13039\/501100010854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82341203"],"award-info":[{"award-number":["82341203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Primary central nervous system lymphoma (PCNSL) has poor outcomes despite high\u2010dose methotrexate\u2010based therapy. The Endothelial Activation and Stress Index (EASIX) is associated with prognosis in systemic lymphomas but has not been evaluated in PCNSL. Define the association of baseline EASIX in multivariate analysis with Memorial Sloan Kettering Cancer Center (MSKCC) score risk factors. A multicentre retrospective cohort included 128 immunocompetent adults with biopsy\u2010proven diffuse large B\u2010cell PCNSL. EASIX was calculated and the optimal cut\u2010off (0.751) was determined by receiver operating characteristic (ROC) analysis. The primary end\u2010points were overall survival (OS) and progression\u2010free survival (PFS) in the low\u2010EASIX and high\u2010EASIX groups. The median age was 60\u2009years. High EASIX (\u22650.751,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200955) was associated with Eastern Cooperative Oncology Group (ECOG)\u00a0\u22652 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002), elevated lactate dehydrogenase (LDH) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), deep brain lesions (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007) and cellular myelocytomatosis oncogene\/B\u2010cell lymphoma\u20102 (MYC\/BCL\u20102) double expression (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01). After a median follow\u2010up of 37\u2009months, high EASIX was associated with inferior OS (27.4\u2009months vs. not reached;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) and PFS (25.6\u2009months vs. not reached;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Multivariable Cox analysis confirmed high EASIX as an independent adverse factor for OS (hazard ratio [HR] 4.75) and PFS (HR 4.99), with additional prognostic discrimination within MSKCC risk groups. Baseline EASIX could potentially improve risk stratification and prognostic modelling in PCNSL.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70641","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T09:18:41Z","timestamp":1782983921000},"page":"1047-1056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Endothelial Activation and Stress Index (\n                    <scp>EASIX<\/scp>\n                    ) at diagnosis is associated with survival in primary central nervous system lymphoma"],"prefix":"10.1111","volume":"209","author":[{"given":"Huanhuan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Haematology, Key Laboratory of Bone\u2010Marrow Stem Cells, Institute of Blood Diseases The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Haematology, Key Laboratory of Bone\u2010Marrow Stem Cells, Institute of Blood Diseases The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Haematology Yantai Yuhuangding Hospital  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxia","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Haematology, Key Laboratory of Bone\u2010Marrow Stem Cells, Institute of Blood Diseases The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Haematology, Key Laboratory of Bone\u2010Marrow Stem Cells, Institute of Blood Diseases The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Haematology, Key Laboratory of Bone\u2010Marrow Stem Cells, Institute of Blood Diseases The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Haematology, Key Laboratory of Bone\u2010Marrow Stem Cells, Institute of Blood Diseases The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Haematology, Key Laboratory of Bone\u2010Marrow Stem Cells, Institute of Blood Diseases The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hujun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Haematology, Key Laboratory of Bone\u2010Marrow Stem Cells, Institute of Blood Diseases The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8547-711X","authenticated-orcid":false,"given":"Xiaofeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Haematology The Second Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lele","family":"Xiao","sequence":"additional","affiliation":[{"name":"Medical Affair Department The Affiliated Hospital of Xuzhou Medical University  Xuzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licai","family":"An","sequence":"additional","affiliation":[{"name":"Department of Haematology Yantai Yuhuangding Hospital  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Haematology, Key Laboratory of Bone\u2010Marrow Stem Cells, Institute of Blood Diseases The Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.8819"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.7667"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010023\u201000439\u20100"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noac196"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001582\u20105"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(23)00371\u2010X"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17747"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/noajnl\/vdaf090"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(17)30108\u20104"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.20210"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102023\u2010007635"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003885"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.70146"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15020185"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10194373"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408\u2010019\u20100247\u2010z"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010020\u201007317\u2010y"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010023\u201007193\u20107"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010022\u201006676\u20103"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2025.2519974"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.164"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2024.115068"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010022\u201009915\u20104"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094\u2010024\u201003771\u20103"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.928"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2872"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.14159"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17357"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(24)00104\u20102"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70641","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:03:17Z","timestamp":1789192997000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/bjh.70641"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70641","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]},"assertion":[{"value":"2026-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}