{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:13:36Z","timestamp":1789193616247,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Early relapse remains a major limitation of chimeric antigen receptor T cell (CAR\u2010T) in relapsed or refractory large B\u2010cell lymphoma (LBCL), particularly for high\u2010risk disease or suboptimal early response. The prospective RESTART protocol evaluated a risk\u2010adapted integration of radiotherapy (RT) with CAR\u2010T. Patients were assigned to RT\u2010dominant (Pathway A) or systemic bridging (Pathway B) based on disease distribution and biology. A key innovation was response\u2010adapted consolidation RT for patients with Deauville score (DS) 4\u20135 at 1\u2010month post\u2010infusion, or DS 3 and baseline high\u2010risk lesions (\u22655\u2009cm and\/or maximum standard uptake value [SUVmax] \u226515). Consolidation RT was delivered 6\u20138\u2009weeks post\u2010infusion using CAR\u2010T\u2013sparing techniques to minimise circulating blood dose. Among 190 patients, 55 (29%) received RT. Local control within irradiated volumes was 89%, including 92% following consolidation RT. At a median follow\u2010up of 12.4\u2009months, the 1\u2010year progression\u2010free survival (PFS) and overall survival (OS) for the entire cohort were 57% and 71% respectively. Patients receiving consolidation RT, despite high\u2010risk features, achieved a 1\u2010year PFS of 54% and OS of 95% with no evidence of excess systemic relapse due to a negative effect on CAR\u2010T. This protocol demonstrates that response\u2010adapted, CAR\u2010T\u2013sparing consolidation RT is feasible and associated with favourable outcomes in high\u2010risk LBCL.<\/jats:p>","DOI":"10.1111\/bjh.70653","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:35:16Z","timestamp":1783082116000},"page":"1239-1247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Response\u2010adapted chimeric antigen receptor T cell (CAR\u2010T)\u2013sparing consolidation radiotherapy in high\u2010risk large\u00a0B\u2010cell lymphoma (LBCL): Results of the prospective\n                    <scp>RESTART<\/scp>\n                    protocol"],"prefix":"10.1111","volume":"209","author":[{"given":"N. 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