{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:12:15Z","timestamp":1789193535822,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Cytomegalovirus (CMV) reactivation is a frequent complication after allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT), but the timing and duration of letermovir prophylaxis in routine practice remain uncertain. We retrospectively reviewed 97 allo\u2010HSCT recipients who received letermovir as primary prophylaxis, focusing on CMV\u2010related outcomes, transplant complications, survival and safety. Letermovir was initiated on day 0 in 31 patients, on day +7 in 44 patients, and on day +14 in 22 patients. The cohort was also stratified by prophylaxis duration, with 51 patients receiving 100\u2010day prophylaxis and 46 patients receiving 200\u2010day prophylaxis. Earlier initiation was associated with a lower 100\u2010day cumulative incidence (CIR) of CMV DNAemia\/csCMVi (6.5% vs. 18.2% vs. 36.4%; Gray's test\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.008), later first CMV deoxyribonucleic acid (DNA) detection (median 78 vs. 54 vs. 36\u2009days;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005) and a shorter duration of DNAemia. Compared with the 200\u2010day group, the 100\u2010day group had more late CMV reactivation after discontinuation during follow\u2010up (21.6% vs. 0%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and numerically lower 1\u2010year overall survival (80.4% [95% confidence interval (CI), 66.6\u201388.9] vs. 93.5% [95% CI, 81.1\u201397.8]; log\u2010rank\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.103), without more severe chronic graft\u2010versus\u2010host disease or grade \u22653 drug\u2010related adverse events. These real\u2010world findings suggest that both earlier initiation and longer letermovir prophylaxis deserve further evaluation after allo\u2010HSCT.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70655","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:10:35Z","timestamp":1783901435000},"page":"1198-1207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A real\u2010world study on different initiation times and treatment durations of letermovir for cytomegalovirus prophylaxis after allogeneic haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"209","author":[{"given":"Shiyu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Hematology, Clinical College of Shenzhen Second People's Hospital Anhui Medical University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4226-8135","authenticated-orcid":false,"given":"Zhihang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical College of Shenzhen Second People's Hospital Anhui Medical University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical College of Shenzhen Second People's Hospital Anhui Medical University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical College of Shenzhen Second People's Hospital Anhui Medical University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9707-5496","authenticated-orcid":false,"given":"Xin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical College of Shenzhen Second People's Hospital Anhui Medical University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1518275"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023012175"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44313-025-00081-7"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05265-11"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706640"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-022-01863-8"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-024-02201-w"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad169"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-023-01920-w"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-197410000-00001"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44466-025-00008-y"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217264"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(15)00289-6"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.05.020"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-679639"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-023-05474-1"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2024.106220"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010966"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2020.10.009"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00344-7"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-022-03348-2"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004362"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008047"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac687"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2022.05.019"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30107-0"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(25)00069-6"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2021.05.001"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2024.286265"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41669-023-00398-y"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70655","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.70655","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.70655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:02:56Z","timestamp":1789192976000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.70655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,12]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/bjh.70655"],"URL":"https:\/\/doi.org\/10.1111\/bjh.70655","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,12]]},"assertion":[{"value":"2026-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}