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Retention of exon 9a between exon 8 and 9 of the\n                    <jats:italic>ETO<\/jats:italic>\n                    (RUNX1 Partner Transcriptional Co\u2010Repressor 1, also name RUNX1T1) gene generates the oncogenic AML1\u2010ETO9a (AE9a) splice variant. Here, we uncover the potential involvement of RNA (ribonucleic acid) helicase DHX15 (DEAH\u2010box helicase 15) in AE9a splicing and AML progression. Clinically, higher expressed\n                    <jats:italic>DHX15<\/jats:italic>\n                    is associated with increased\n                    <jats:italic>AE9a\/AE<\/jats:italic>\n                    abundance and poor outcomes in AE\u2010positive (AE\n                    <jats:sup>+<\/jats:sup>\n                    ) AML patients. DHX15 knockdown impaired cell proliferation, induced S\/G2 cell\u2010cycle arrest in\u00a0vitro and prolonged overall survival in AE\n                    <jats:sup>+<\/jats:sup>\n                    leukaemia\u2010bearing mice in\u00a0vivo. In addition, DHX15 knockdown reduced AE and AE9a expression, and RNA immunoprecipitation revealed DHX15 bound to\n                    <jats:italic>AE<\/jats:italic>\n                    and\n                    <jats:italic>AE9a<\/jats:italic>\n                    transcripts and RNA pull\u2010down assay showed a selective interaction of HNRNPL and RBM33 with\n                    <jats:italic>AE9a<\/jats:italic>\n                    transcripts. Three\u2010dimensional structure prediction suggests a sophisticated regulatory complex formation involving DHX15, HNRNPL (heterogeneous nuclear ribonucleoprotein L) and RBM33 (RNA binding motif protein 33). Further,\n                    <jats:italic>HNRNPL<\/jats:italic>\n                    and\n                    <jats:italic>RBM33<\/jats:italic>\n                    gene expression positively correlated with\n                    <jats:italic>AE9a<\/jats:italic>\n                    levels in AE\n                    <jats:sup>+<\/jats:sup>\n                    AML samples. Downregulation of\n                    <jats:italic>HNRNPL<\/jats:italic>\n                    and\n                    <jats:italic>RBM33<\/jats:italic>\n                    reduced\n                    <jats:italic>AE9a<\/jats:italic>\n                    expression in Kasumi\u20101 cells. Collectively, our findings support an association between DHX15, HNRNPL, RBM33 and AE9a splicing and suggest their contribution to leukemogenic progression in AE\n                    <jats:sup>+<\/jats:sup>\n                    AML.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70658","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T06:35:16Z","timestamp":1783924516000},"page":"964-977","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>DHX15<\/scp>\n                    affects\n                    <scp>AML1<\/scp>\n                    \u2010\n                    <scp>ETO9a<\/scp>\n                    splicing together with\n                    <scp>HNRNPL<\/scp>\n                    ,\n                    <scp>RBM33<\/scp>\n                    in\n                    <scp>AML1<\/scp>\n                    \u2010\n                    <scp>ETO<\/scp>\n                    \u2010positive acute myeloid leukaemia"],"prefix":"10.1111","volume":"209","author":[{"given":"Qiao","family":"Liu","sequence":"first","affiliation":[{"name":"Fujian Provincial Key Laboratory on Hematology, Department of Hematology Fujian Institute of Hematology, Fujian Medical University Union Hospital  Fuzhou China"},{"name":"Union Clinical Medical Colleges, Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechun","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory on Hematology, Department of Hematology Fujian Institute of Hematology, Fujian Medical University Union Hospital  Fuzhou China"},{"name":"Union Clinical Medical Colleges, Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiqiang","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Xiamen University  Xiamen Fujian Province 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