{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T03:30:51Z","timestamp":1786505451688,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL133049"],"award-info":[{"award-number":["HL133049"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL139489"],"award-info":[{"award-number":["HL139489"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001873"],"award-info":[{"award-number":["UL1TR001873"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    To compare physiologically based serum hepcidin and ferritin thresholds for iron deficiency in adult female and male blood donors, we analysed laboratory results obtained during screening for a blood donor study. In 907 apparently healthy blood donors, we examined the relationships of hepcidin and ferritin with five indicators of the onset of iron\u2010deficient red blood cell production: haemoglobin (Hb), soluble transferrin receptor (sTfR), erythrocyte zinc protoporphyrin (ZPP), reticulocyte haemoglobin content (Retic\u2010Hb) and mean corpuscular volume (MCV). Serum hepcidin and ferritin were correlated (Pearson's\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.69,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009&lt;0.001 females;\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.65,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001, males). At lower serum hepcidin and ferritin concentrations, Hb, Retic\u2010Hb and MCV decreased and sTfR and ZPP increased. Using restricted cubic spline models, the hepcidin thresholds for iron deficiency in adult female donors 18\u201349\u2009years, 50\u201375\u2009years and all male blood donors 18\u201375\u2009years old were 13.9, 24.8 and 28.8\u2009\u03bcg\/L respectively. The corresponding ferritin thresholds were 25.4, 30.7 and 32.5\u2009\u03bcg\/L respectively. Among blood donors 18\u201350\u2009years old, serum hepcidin and ferritin thresholds for iron deficiency were lower in women than in men but were similar after 50\u2009years of age. In conclusion, among adult blood donors, serum hepcidin and ferritin thresholds are similarly effective for detecting iron deficiency, especially among women.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70662","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T23:31:24Z","timestamp":1783639884000},"page":"724-733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Physiologically based serum hepcidin and ferritin thresholds identify similar onsets of iron\u2010deficient erythropoiesis in adult blood donors"],"prefix":"10.1111","volume":"209","author":[{"given":"O. Yaw","family":"Addo","sequence":"first","affiliation":[{"name":"Nutrition Branch, Division of Nutrition, Physical Activity and Obesity Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary M.","family":"Brittenham","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, College of Physicians and Surgeons Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuguo","family":"Mei","sequence":"additional","affiliation":[{"name":"Nutrition Branch, Division of Nutrition, Physical Activity and Obesity Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena D.","family":"Jefferds","sequence":"additional","affiliation":[{"name":"Nutrition Branch, Division of Nutrition, Physical Activity and Obesity Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael C.","family":"Flores\u2010Ayala","sequence":"additional","affiliation":[{"name":"Nutrition Branch, Division of Nutrition, Physical Activity and Obesity Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daysha","family":"Fliginger","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Lipschitz","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Spitalnik","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eldad A.","family":"Hod","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","first-page":"1","article-title":"Recommendations to prevent and control iron deficiency in the United States. 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