{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:37:18Z","timestamp":1791301038234,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["21ck0106433h0004"],"award-info":[{"award-number":["21ck0106433h0004"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K11508"],"award-info":[{"award-number":["JP24K11508"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Treatment\u2010free remission (TFR) is now a key goal for chronic\u2010phase chronic myeloid leukaemia (CML\u2010CP) after achievement of a prolonged deep molecular response. About half of these patients can remain in remission without treatment, whereas those who relapse must resume lifelong therapy. This study investigated whether patients who previously failed tyrosine kinase inhibitor discontinuation could achieve TFR after receiving ponatinib as maintenance therapy. Patients who had relapsed after prior tyrosine kinase inhibitor (TKI) discontinuation and subsequently regained molecular response 4.5 (MR4.5;\u00a0defined as a\n                    <jats:italic>BCR\u2010ABL1<\/jats:italic>\n                    transcript level\u00a0\u22640.0032% on the International Scale [IS])\u00a0were enrolled, switched to ponatinib (15\u2009mg\/day) for 12\u2009months and those who maintained MR4.5 discontinued TKI therapy. The primary end\u2010point was the proportion of patients with TFR at 12\u2009months. Patients losing major molecular response (MMR) resumed ponatinib or their prior TKI. Of 50 enrolled patients, 49 received ponatinib and 41 proceeded to TKI discontinuation. At 12\u2009months, the proportion of patients with TFR was 36.6% (90% confidence interval: 24.1\u201350.6). Univariate analysis identified favourable factors for TFR: first discontinuation of imatinib, longer initial TKI therapy and longer first TFR duration. In conclusion, ponatinib maintenance followed by a second attempt at TKI discontinuation may facilitate successful TFR in selected CML patients. However, the risk of adverse events highlights the need for careful patient selection.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70678","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T09:05:46Z","timestamp":1783587946000},"page":"1111-1118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reattempt of tyrosine kinase inhibitor discontinuation after maintenance therapy with ponatinib in patients with chronic myeloid leukaemia in the chronic phase: Result of the\n                    <scp>Japan Adult Leukemia Study Group RE<\/scp>\n                    \u2010\n                    <scp>STOP219<\/scp>\n                    study"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9176-1988","authenticated-orcid":false,"given":"Noriyoshi","family":"Iriyama","sequence":"first","affiliation":[{"name":"Division of Hematology and Rheumatology, Department of Medicine Nihon University School of Medicine  Tokyo Japan"},{"name":"Department of Hematology and Rheumatology NHO Saitama Hospital  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6758-3787","authenticated-orcid":false,"given":"Naoto","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nephrology, and Rheumatology Akita University School of Medicine  Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumichi","family":"Fujimaki","sequence":"additional","affiliation":[{"name":"Department of Hematology Fujisawa City Hospital  Fujisawa Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Ono","sequence":"additional","affiliation":[{"name":"Division of Transfusion and Cell Therapy Hamamatsu University Hospital  Shizuoka 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