{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:27:55Z","timestamp":1793114875605,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Advanced\u2010stage classical Hodgkin lymphoma (cHL) has been traditionally treated with effective chemotherapy regimens, albeit some associated with substantial toxicity. The recently introduced brentuximab vedotin, etoposide, cyclophosphamide, doxorubicin, dacarbazine, dexamethasone (BrECADD) regimen has proved more effective and less toxic than escalated BEACOPP (escBEACOPP: bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine, procarbazine, prednisone). Our retrospective multicentre study assessed outcomes of this treatment in the real\u2010world setting. It incorporated 100 advanced\u2010stage cHL patients receiving BrECADD at 19 cancer centres between July 2023 and October 2025. The primary end\u2010point was progression\u2010free survival (PFS); secondary end\u2010points included overall response rate (ORR), positron emission tomography (PET)\u20102 negativity, complete response (CR), overall survival (OS) and toxicity. The median age was 30 (18\u201365) years; 80% had stage IV disease; 85% had an International Prognostic Score \u22653. ORR and CR were 100% and 95%, respectively; 83% achieved PET\u20102 negativity, enabling therapy de\u2010escalation from six to four cycles. At a median follow\u2010up of 13.7\u2009months, estimated 1\u2010year PFS and OS were 96% and 100% respectively. Only 4% required radiotherapy. Grade \u22653 neutropenia (83%) and febrile neutropenia (55%) were common; yet, 95% of patients completed all planned cycles. Peripheral neuropathy occurred in 25%, mostly grade 1\u20132. In this real\u2010world cohort, including high\u2010risk patients, BrECADD demonstrated remarkable efficacy and tolerability, supporting its feasibility and potential to reduce chemotherapy and radiotherapy exposure, while maintaining high treatment efficacy.<\/jats:p>","DOI":"10.1111\/bjh.70682","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T02:32:58Z","timestamp":1784082778000},"page":"1039-1046","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010world outcomes of\n                    <scp>BrECADD<\/scp>\n                    therapy in advanced\u2010stage classical Hodgkin lymphoma: A multicentre retrospective study"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3036-3561","authenticated-orcid":false,"given":"Tzvika","family":"Porges","sequence":"first","affiliation":[{"name":"Institute of Hematology Soroka University Medical 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