{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:49:32Z","timestamp":1792158572371,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:00:00Z","timestamp":1784419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100015459","name":"Danish Cancer Society Research Center","doi-asserted-by":"publisher","award":["R223\u2010A13071"],"award-info":[{"award-number":["R223\u2010A13071"]}],"id":[{"id":"10.13039\/100015459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015459","name":"Danish Cancer Society Research Center","doi-asserted-by":"publisher","award":["R352\u2010A20533"],"award-info":[{"award-number":["R352\u2010A20533"]}],"id":[{"id":"10.13039\/100015459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF24OC0088756"],"award-info":[{"award-number":["NNF24OC0088756"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Mosaic chromosomal alterations (mCAs) are large somatic gains, losses and copy\u2010neutral loss of heterozygosity identified in the peripheral blood, which represent a relatively unexplored spectrum of clonal haematopoiesis. We aimed to describe mCAs in two large Danish cohorts with extensive long\u2010term registry\u2010based follow\u2010up and examine associations with haematological malignancy. We analysed genotype data from 97\u2009752 participants from the Danish Blood Donor Study and 86\u2009301 patients from the Copenhagen Hospital Biobank using the MoChA software. Association to haematological cancers was modelled with competing\u2010risk methods and Cox regression, or logistic regression, via nationwide register linkage. Among 184\u2009053 individuals, 15\u2009459 (8%) carried autosomal mCAs and 14\u2009322 females (17%) had loss of X, with prevalence increasing with age. In samples before or after diagnosis of haematological cancer, autosomal mCAs were detectable in 21%\u201362% of individuals depending on cancer subtype. Overall, the risk of haematological cancer was increased for individuals carrying autosomal mCA (hazard ratio [HR] 4.1 (95% confidence interval [CI] 3.1\u20135.5)), but not for individuals carrying loss of X chromosome (HR 1.1 [95% CI 0.7\u20131.6]). The level of malignancy risk was highly variable between different chromosomal aberrations, and cancer gene\u2013related mCAs conveyed highest risk. Autosomal mCAs, especially those overlapping cancer gene loci, identify individuals at increased risk of haematological malignancy and may assist improvement of risk stratification and early detection.<\/jats:p>","DOI":"10.1111\/bjh.70688","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:26:52Z","timestamp":1784507212000},"page":"1549-1561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mosaic chromosomal alterations and relation to haematological cancer in two large Danish cohorts"],"prefix":"10.1111","volume":"209","author":[{"given":"Cecilie Velsoe","family":"Maeng","sequence":"first","affiliation":[{"name":"Department of Haematology Copenhagen University Hospital, Rigshospitalet  Copenhagen N Denmark"},{"name":"Biotech Research and Innovation Center (BRIC) University of Copenhagen  Copenhagen Denmark"},{"name":"Danish Cancer Institute  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Meng","sequence":"additional","affiliation":[{"name":"Biotech Research and Innovation Center (BRIC) University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2678-3976","authenticated-orcid":false,"given":"Mathias","family":"Heldbo","sequence":"additional","affiliation":[{"name":"Department of Haematology Copenhagen University Hospital, Rigshospitalet  Copenhagen N Denmark"},{"name":"Biotech Research and Innovation Center (BRIC) University of Copenhagen  Copenhagen Denmark"},{"name":"The Finsen Laboratory Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7226-5409","authenticated-orcid":false,"given":"Olafur","family":"Davidsson","sequence":"additional","affiliation":[{"name":"Danish Cancer Institute  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten Munk","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Haematology Copenhagen University Hospital, Rigshospitalet  Copenhagen N Denmark"},{"name":"Biotech Research and Innovation Center (BRIC) University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigr\u00fan","family":"Thorsteinsd\u00f3ttir","sequence":"additional","affiliation":[{"name":"Department of Haematology Copenhagen University Hospital, Rigshospitalet  Copenhagen N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3138-4591","authenticated-orcid":false,"given":"Jojo Biel\u2010Nielsen","family":"Dietz","sequence":"additional","affiliation":[{"name":"Danish Cancer Institute  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragnar P\u00e9tur","family":"Kristjansson","sequence":"additional","affiliation":[{"name":"Danish Cancer Institute  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Birger Vesterager","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Zealand University Hospital  K\u00f8ge Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Erikstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2945-6197","authenticated-orcid":false,"given":"Christina","family":"Mikkelsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanna","family":"Br\u00f8ns","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Ullum","sequence":"additional","affiliation":[{"name":"Statens Serum Institut Danish Ministry of Health  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bitten","family":"Aagaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mie Topholm","family":"Bruun","sequence":"additional","affiliation":[{"name":"Clinical Immunology Research Unit, Department of Clinical Immunology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estrid","family":"H\u00f8gdall","sequence":"additional","affiliation":[{"name":"Molecular Unit, Department of Pathology, Bio\u2010 and GenomeBank Denmark, Herlev Hospital University of Copenhagen  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"DBDS Research Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"CHB Research Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Porse","sequence":"additional","affiliation":[{"name":"Biotech Research and Innovation Center (BRIC) University of Copenhagen  Copenhagen Denmark"},{"name":"The Finsen Laboratory Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Husby","sequence":"additional","affiliation":[{"name":"Department of Haematology Copenhagen University Hospital, Rigshospitalet  Copenhagen N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisse R.","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Immunology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hjalgrim","sequence":"additional","affiliation":[{"name":"Department of Haematology Copenhagen University Hospital, Rigshospitalet  Copenhagen N Denmark"},{"name":"Danish Cancer Institute  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1535-9601","authenticated-orcid":false,"given":"Kirsten","family":"Gr\u00f8nb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Haematology Copenhagen University Hospital, Rigshospitalet  Copenhagen N Denmark"},{"name":"Biotech Research and Innovation Center (BRIC) University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen 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