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It remains unclear whether venetoclax, an anti\u2010leukaemic agent, can enhance RIC efficacy. A prospective, single\u2010arm, phase 2 trial enrolled patients with high\u2010risk AML or MDS, aged \u226555\u2009years, who underwent allogeneic peripheral blood stem cell transplantation (allo\u2010PBSCT). All patients received venetoclax\u2010enhanced RIC (VEN\u2010RIC), comprising venetoclax, busulfan, fludarabine, cytarabine and low\u2010dose total body irradiation (TBI). Fifty patients (median age 62) were enrolled. At a median follow\u2010up of 14.9\u2009months, the 1\u2010year progression\u2010free survival (PFS) was 72.5%, while 1\u2010year overall survival (OS) and graft\u2010versus\u2010host disease\/relapse\u2010free survival (GVHD\/GRFS) were 73.8% and 56.9% respectively. The 1\u2010year cumulative incidence of relapse and non\u2010relapse mortality were 16.8% and 10.6%. The 180\u2010day cumulative incidence of acute GVHD was 22.9%, while the 1\u2010year cumulative incidence of chronic GVHD was 25.8%. Multivariable analysis showed\n                    <jats:italic>TP53<\/jats:italic>\n                    mutation was the strongest predictor of worse OS, PFS and GRFS, as well as higher relapse. We conclude that VEN\u2010RIC is feasible and associated with encouraging survival and a manageable safety profile, warranting confirmation in randomized studies.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70690","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:48:26Z","timestamp":1784166506000},"page":"1773-1782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Venetoclax\u2010enhanced reduced\u2010intensity conditioning in older patients aged \u226555\u2009years with high\u2010risk myeloid malignancies undergoing allogeneic peripheral blood stem cell transplantation: A phase\n                    <scp>II<\/scp>\n                    study"],"prefix":"10.1111","volume":"209","author":[{"given":"Jie","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Hematology, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 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