{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:12:11Z","timestamp":1789193531897,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT) is an effective treatment for patients with haematological malignancies; however, post\u2010transplant complications, including infections and acute graft\u2010versus\u2010host disease (aGvHD), remain significant issues. Identifying modifiable risk factors is therefore critical to improve patient outcomes. This retrospective study evaluated the impact of hyperglycaemia on post\u2010transplant outcomes in adult patients undergoing allo\u2010HSCT at the University Medical Centre Groningen between 2018 and 2024. Hyperglycaemia was defined as a glucose level exceeding 10\u2009mmol\/L in capillary or venous samples. In total, 575 patients were included. The median age was 61\u2009years (interquartile range [IQR]: 52\u201368); 64% were male, and the median body mass index (BMI) was 25.3\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    (IQR: 23.1\u201328.0). During hospitalization, 26.6% of patients experienced at least one episode of hyperglycaemia. After adjusting for confounding variables, hyperglycaemia was associated with significantly reduced 100\u2010day overall survival (hazard ratio [HR] 2.36, 95% confidence interval [CI] 1.29\u20134.33). It was also linked to an increased risk of severe (grade \u22653) aGvHD and infections. Importantly, hyperglycaemia occurring within 30\u2009days prior to transplantation already predicted poorer survival. In conclusion, hyperglycaemia at any moment during allo\u2010HSCT is predictive for treatment\u2010related adverse events. Since glucose levels are highly modifiable, closer attention and timely intervention might improve outcomes.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70692","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:59:59Z","timestamp":1784293199000},"page":"1220-1229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyperglycaemia as a predictor of morbidity and mortality in patients receiving an allogeneic haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3561-5358","authenticated-orcid":false,"given":"Marieke","family":"Tienstra","sequence":"first","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fleur R.","family":"Goemans","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Keijzer","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen The Netherlands"},{"name":"Department of Radiation Oncology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge V. G.","family":"Oteman","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carin L. E.","family":"Hazenberg","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap A.","family":"van Doesum","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne G. H.","family":"Niezink","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goda","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerwin A.","family":"Huls","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Medical Center Groningen  Groningen The Netherlands"},{"name":"Department of Internal Medicine Isala  Zwolle The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde A. M.","family":"Kooistra","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5581-6950","authenticated-orcid":false,"given":"Tom","family":"van Meerten","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linde M.","family":"Morsink","sequence":"additional","affiliation":[{"name":"Department of Hematology University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","unstructured":"SchlaakM.Allogeneic stem cell transplantation versus conventional therapy for advanced primary cutaneous T\u2010cell lymphoma.2012Cochrane Library. 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