{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:12:11Z","timestamp":1789193531921,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Immunoglobulin M\u2010related peripheral neuropathy (IgM\u2010PN) is typically demyelinating and associated with anti\u2010myelin\u2010associated glycoprotein antibodies; however, limited data on clinical outcomes are available. We retrospectively analysed consecutive patients with IgM\u2010PN assessed prospectively with the Rasch\u2010built Overall Disability Scale (RODS) and the Inflammatory Neuropathy Cause and Treatment (INCAT) questionnaires. Twenty\u2010eight patients were retrospectively enrolled. The median follow\u2010up was 5.54\u2009years. Treatment was initiated in all solely due to neuropathy symptoms: 19 (67.9%) dexamethasone\u2010rituximab\u2010cyclophosphamide, 6 (21.4%) rituximab and 3 (10.7%) ibrutinib. The baseline median INCAT score was 2.0 and improved to 1.0 at further time points; within\u2010patient improvements compared to baseline were significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.005). A clinically relevant improvement was evident in 13 (46.4%), 18 (64.3%) and 17 (60.7%) patients at 6, 12 and 24\u2009months respectively. IgM reduction was associated with improvement in INCAT scores at 6 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.041) and 12\u2009months (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.030). At baseline, the median RODS score was 38.0, improved to 41.5 at 6\u2009months, then to 43.0 and 43.5 at 1 and 2\u2009years (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). A clinically relevant improvement was evident in 5 (17.9%), 7 (25%) and 9 (32.1%) patients at 6, 12 and 24\u2009months respectively. Patients with IgM\u2010PN, treated mainly with rituximab\u2010based regimens, showed significant improvement in functional and neurological ability over a 2\u2010year follow\u2010up.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70693","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:41:43Z","timestamp":1784608903000},"page":"1031-1038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management and long\u2010term haematological and neurological outcomes of\n                    <scp>Immunoglobulin M<\/scp>\n                    and Waldenstr\u00f6m's macroglobulinaemia\u2010related neuropathy: A single\u2010centre experience"],"prefix":"10.1111","volume":"209","author":[{"given":"Maria","family":"Gavriatopoulou","sequence":"first","affiliation":[{"name":"Department of Clinical Therapeutics Alexandra General Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6328-9783","authenticated-orcid":false,"given":"Ioannis","family":"Ntanasis\u2010Stathopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics Alexandra General Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8971-269X","authenticated-orcid":false,"given":"Charalampos","family":"Filippatos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics Alexandra General Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Malandrakis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics Alexandra General Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios","family":"Manganas","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics Alexandra General Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6926-0351","authenticated-orcid":false,"given":"Foteini","family":"Theodorakakou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics Alexandra General Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Solia","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics Alexandra General Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Eleutherakis\u2010Papaiakovou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics Alexandra General Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Katsadouros","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics Alexandra General Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Boutsikos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics Alexandra General Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0618-8900","authenticated-orcid":false,"given":"Despina","family":"Fotiou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics Alexandra General Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-2447","authenticated-orcid":false,"given":"Magdalini","family":"Migkou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics Alexandra General Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Kanellias","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics Alexandra General Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Terpos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics Alexandra General Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-5832","authenticated-orcid":false,"given":"Efstathios","family":"Kastritis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics Alexandra General Hospital, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meletios\u2010Athanasios","family":"Dimopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics Alexandra General Hospital, National and Kapodistrian University of Athens  Athens Greece"},{"name":"Department of Medicine Korea University  Seoul South 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