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Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018866","name":"Paula and Rodger Riney Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Deletion (13q)\/monosomy 13 (del[13q]\/\u221213) is common in multiple myeloma (MM), but its independent prognostic value remains unclear, particularly in patients treated with modern therapy and upfront autologous haematopoietic stem cell transplantation (autoHSCT). This study aimed to assess its impact on progression\u2010free survival (PFS) and overall survival (OS), and to evaluate its prognostic impact in the context of established high\u2010risk cytogenetic abnormalities (HRCA). We conducted a retrospective, single\u2010centre study of MM patients undergoing autoHSCT between 2010 and 2021 with available fluorescence in\u00a0situ hybridization results. Among 1680 patients, del(13q)\/\u221213 was identified in 591 (35.2%). Compared with patients without HRCA or del(13q)\/\u221213, isolated del(13q)\/\u221213 was associated with shorter median PFS (37.3 vs. 64.6\u2009months) and OS (105.4 vs. 131.0\u2009months). Patients with concurrent HRCA and del(13q)\/\u221213 had the poorest outcomes, with median PFS and OS of 33.9 and 81.6\u2009months, respectively. Multivariable Cox regression confirmed that isolated\/non\u2010HRCA\u2010associated del(13q)\/\u221213, was independently associated with inferior PFS (hazard ratio [HR] 1.36, 95% confidence interval [CI]: 1.17\u20131.58,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0001) and OS (HR 1.49, 95% CI: 1.21\u20131.84,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0002). Del(13q)\/\u221213 is independently associated with inferior PFS and OS in MM patients undergoing autoHSCT, with an additive adverse effect when co\u2010occurring with HRCA.\n                  <\/jats:p>","DOI":"10.1111\/bjh.70694","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:12:04Z","timestamp":1784877124000},"page":"1185-1197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic impact of monosomy 13 and deletion of 13q in multiple myeloma patients undergoing upfront autologous transplantation"],"prefix":"10.1111","volume":"209","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2806-2583","authenticated-orcid":false,"given":"Damian M.","family":"Mikulski","sequence":"first","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center  Houston Texas USA"},{"name":"Department of Biostatistics and Translational Medicine Medical University of Lodz  Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis","family":"Marcoux","sequence":"additional","affiliation":[{"name":"Division of Hematology Dalhousie University  Halifax Nova Scotia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Tanner","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qaiser","family":"Bashir","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas 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Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1649-7651","authenticated-orcid":false,"given":"Yosra","family":"Aljawai","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8545-3292","authenticated-orcid":false,"given":"Hans C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krina K.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Lymphoma and Myeloma The University of Texas MD Anderson Cancer Center  Houston Texas 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